Evidence map›Paper›PMID 37373727›Full record

ArticleJournal of clinical medicine2023

Diagnostic Performance and Cell Count of EBUS-TBNA Needle Gauges: A Prospective Trial.

Juliana Guarize, Cristina Diotti, Monica Casiraghi, Stefano Donghi, Clementina Di Tonno, Patrizia Mancuso, Laura Zorzino, Giulia Sedda, Davide Radice, Luca Bertolaccini and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Juliana GuarizeInterventional Pulmonology Unit, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-1695-1375
Cristina DiottiDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0001-8619-961X
Monica CasiraghiDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0001-5986-7811
Stefano DonghiInterventional Pulmonology Unit, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Clementina Di TonnoDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Patrizia MancusoDivision of Clinical Hemato-Oncology Laboratory, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Laura ZorzinoDivision of Laboratory Medicine, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-8596-1649
Giulia SeddaDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0002-7482-1544
Davide RadiceDivision of Epidemiology and Biostatistics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-5075-1895
Luca BertolacciniDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0002-1153-3334
Lorenzo SpaggiariDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
European Institute of Oncology · ITRipamonti · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Milan · IT

Funding

Ministero della Salute 5 x 1000Ministero della Salute ricerca corrente
6 · The paper itself

Abstract

backgroundEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic procedure for evaluating hilar and mediastinal lymphadenopathies and is the gold standard for lung cancer diagnosis and staging. Recent studies assessed the effectiveness of the 19-G flex needle in obtaining larger EBUS-TBNA samples, and prospective small series gave similar results in terms of diagnostic yield when testing different gauge needles. The lack of homogeneity between series and the small sample size of some prospective cohorts poses a limit to the validity of those results. This prospective controlled study compared the 19-G flex and 22-G needles in terms of diagnostic yield. An objective laboratory method was used to count cells and compare the two needles' cytologic yields. MATERIAL: A prospective controlled study was conducted on 90 patients undergoing EBUS-TBNA for the diagnosis of hilar and mediastinal lymphadenopathies. The institutional ethic committee (IEO573) approved the study, and informed consent was obtained from all patients.

resultsA total of 90 patients were enrolled in this study, 84.4% of whom were diagnosed with malignancy and 15.6% with non-neoplastic disease. Sensitivity for malignancy was 93.4% (CI: 87.4-97.1%) for the 19-G needle and 92.6% (CI: 86.3-96.5%) for the 22-G needle (

conclusionsThe 19-G flex EBUS-TBNA needle is comparable to the 22-G needle in terms of diagnostic yield for cyto-histological evaluation of hilar and mediastinal lymphadenopathies. There is no difference between the 19-G and 22-G needle cell counts evaluated by flow cytometry.

Indexed as

19-G flex needlecell countdiagnostic yieldendobronchial ultrasound-GUIDED transbronchial needle aspirationlung cancer

Identifiers

PMID37373727
PMCPMC10299412
OpenAlexW4380686338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.