Evidence map›Paper›PMID 37373697›Full record

ArticleJournal of clinical medicine2023

Urokinase versus Alteplase in Patients with Intermediate-High-Risk Pulmonary Embolism Treated with Ultrasound-Accelerated Endovascular Thrombolysis.

Hani Al-Terki, Michael Gotzmann, Felix Mahfoud, Lucas Lauder, Andreas Mügge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hani Al-TerkiCardiology and Rhythmology Department, University Hospital St. Josef Hospital-Bochum, Ruhr University-Bochum, Gudrunstraße 56, 44791 Bochum, Germany.ORCID 0000-0002-8003-9591
Michael GotzmannCardiology and Rhythmology Department, University Hospital St. Josef Hospital-Bochum, Ruhr University-Bochum, Gudrunstraße 56, 44791 Bochum, Germany.
Felix MahfoudKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätskliniken des Saarlandes, Saarland University, 66421 Homburg, Germany.ORCID 0000-0002-4425-549X
Lucas LauderKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätskliniken des Saarlandes, Saarland University, 66421 Homburg, Germany.
Andreas MüggeCardiology and Rhythmology Department, University Hospital St. Josef Hospital-Bochum, Ruhr University-Bochum, Gudrunstraße 56, 44791 Bochum, Germany.ORCID 0000-0001-9548-6995
St. Josef-Hospital · DEUniversitätsklinikum des Saarlandes · DE

Funding

Ruhr University Bochum DE 127056261
6 · The paper itself

Abstract

backgroundUltrasound-accelerated thrombolysis (USAT) is a safe and effective treatment for patients with intermediate-high-risk pulmonary embolism (PE). In all studies investigating USAT in the setting of PE, the recombinant tissue-plasminogen activator (rt-PA) alteplase or actilyse was used. Currently, there is a shortage of alteplase (Alteplase, Boehringer Ingelheim) in Europe. It is unknown whether the efficacy of urokinase (UK) is comparable with alteplase for USAT in patients with PE.

methodsPatients with intermediate-high-risk PE undergoing USAT with urokinase and alteplase were included in this study. One-to-one nearest neighbour matching was performed to account for baseline differences. We identified one patient treated with USAT and UK (

resultsA total of 56 patients underwent USAT. The treatment was successful in all patients. The propensity score matched the identified nine pairs of patients. There were no statistically significant differences in the change in right ventricle-to-left ventricle (RV/LV) ratio (0.4 ± 0.3 versus 0.5 ± 0.4,

conclusionsIn this case-matched comparison, the short-term clinical and echocardiographic outcomes showed comparable results between USAT-UK and USAT-rt-PA.

Indexed as

alteplaseEKOSTMpulmonary embolismurokinaseUSAT

Identifiers

PMID37373697
PMCPMC10299630
OpenAlexW4380632843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.