Evidence map›Paper›PMID 37373661›Full record

ArticleJournal of clinical medicine2023

Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients.

Nathalie Hammer, David Legouis, Andreas Pasch, Aurélie Huber, Lama Al-Qusairi, Pierre-Yves Martin, Sophie de Seigneux, Lena Berchtold

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Nathalie HammerService of Nephrology, Inselspital, 3010 Bern, Switzerland.
David LegouisDivision of Intensive Care, University Hospital of Geneva, 1205 Geneva, Switzerland.
Andreas PaschCalciscon AG, 2503 Biel, Switzerland.ORCID 0000-0002-7439-0748
Aurélie HuberService of Internal Medicine, Hospital La Chaux-de-Fonds, 2000 Neuchatel, Switzerland.
Lama Al-QusairiDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Pierre-Yves MartinService of Nephrology, Department of Internal Medicine Specialties, University Hospital of Geneva, 1205 Geneva, Switzerland.
Sophie de SeigneuxService of Nephrology, Department of Internal Medicine Specialties, University Hospital of Geneva, 1205 Geneva, Switzerland.
Lena BerchtoldService of Nephrology, Department of Internal Medicine Specialties, University Hospital of Geneva, 1205 Geneva, Switzerland.ORCID 0000-0001-8815-4263
University Hospital of Geneva · CHInternational Museum of Horology · CHJohannes Kepler University of Linz · ATJohns Hopkins University · USUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum creatinine level, proteinuria, and interstitial fibrosis are predictive of renal prognosis. Fractional excretion of phosphate (FEP)/FGF23 ratio, tubular reabsorption of phosphate (TRP), serum calcification propensity (T50), and Klotho's serum level are emerging as determinants of poor kidney outcomes in CKD patients. We aimed at analysing the use of FGF23, FEP/FGF23, TRP, T50, and Klotho in predicting the rapid decline of renal function in kidney allograft recipients.

methodsWe included 103 kidney allograft recipients in a retrospective study with a prospective follow-up of 4 years. We analysed the predictive values of FGF23, FEP/FGF23, TRP, T50, and Klotho for a rapid decline of renal function defined as a drop of eGFR > 30%.

resultsDuring a follow-up of 4 years, 23 patients displayed a rapid decline of renal function. Tertile of FGF23 (

conclusionT50 showed a strong association with a rapid decline of renal function in kidney allograft patients. This study underlines its role as an independent biomarker of loss of kidney function. We found no association between other phosphocalcic markers, such as FGF23, FEP/FGF23, TRP and Klotho, with a rapid decline of renal function in kidney allograft recipients.

Indexed as

decline of renal functionkidney transplantphosphocalcic markersprediction

Identifiers

PMID37373661
PMCPMC10298924
OpenAlexW4380360844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.