Evidence map›Paper›PMID 37373540›Full record

ArticleInternational journal of molecular sciences2023

Effects of Modified Glucosamine on the Chondrogenic Potential of Circulating Stem Cells under Experimental Inflammation.

Marco Gasparella, Carola Cenzi, Monica Piccione, Valentina Noemi Madia, Roberto Di Santo, Valeria Tudino, Marco Artico, Samanta Taurone, Chiara De Ponte, Roberta Costi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Heterogeneity and interplay: the multifaceted role of cancer-associated fibroblasts in the tumor and therapeutic strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Marco GasparellaLocal Health Unit Treviso, Department of Pediatric Surgery, 31100 Treviso, Italy.
Carola CenziDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-6000-3444
Monica PiccioneDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-5456-1960
Valentina Noemi MadiaDepartment of Drug Chemistry and Technology, University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-5724-612X
Roberto Di SantoDepartment of Drug Chemistry and Technology, University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-4279-7666
Valeria TudinoDepartment of Drug Chemistry and Technology, University of Rome "La Sapienza", 00185 Rome, Italy.
Marco ArticoDepartment of Sensory Organs, University of Rome "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-8786-7007
Samanta TauroneDepartment of Movement, Human and Health Sciences-Division of Health Sciences, University of Rome "Foro Italico", 00185 Rome, Italy.ORCID 0000-0002-0354-894X
Chiara De PonteDepartment of Sensory Organs, University of Rome "La Sapienza", 00185 Rome, Italy.
Roberta CostiDepartment of Drug Chemistry and Technology, University of Rome "La Sapienza", 00185 Rome, Italy.
Rosa Di LiddoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-7794-6804
Sapienza University of Rome · ITUniversity of Padua · ITAULSS 2 Marca Trevigiana · ITForo Italico University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucosamine (GlcN) is a glycosaminoglycan (GAGs) constituent in connective tissues. It is naturally produced by our body or consumed from diets. In the last decade, in vitro and in vivo trials have demonstrated that the administration of GlcN or its derivates has a protective effect on cartilage when the balance between catabolic and anabolic processes is disrupted and cells are no longer able to fully compensate for the loss of collagen and proteoglycans. To date, these benefits are still controversial because the mechanism of action of GlcN is not yet well clarified. In this study, we have characterized the biological activities of an amino acid (AA) derivate of GlcN, called DCF001, in the growth and chondrogenic induction of circulating multipotent stem cells (CMCs) after priming with tumor necrosis factor-alpha (TNFα), a pleiotropic cytokine commonly expressed in chronic inflammatory joint diseases. In the present work, stem cells were isolated from the human peripheral blood of healthy donors. After priming with TNFα (10 ng/mL) for 3 h, cultures were treated for 24 h with DCF001 (1 μg/mL) dissolved in a proliferative (PM) or chondrogenic (CM) medium. Cell proliferation was analyzed using a Corning

Indexed as

ChondrocytesGlucosamineCell DifferentiationCells, CulturedChondrogenesisHumansInflammationNF-KappaB Inhibitor alphaStem CellsTumor Necrosis Factor-alphaGlucosamineNF-KappaB Inhibitor alphaTumor Necrosis Factor-alphacartilageCD73glucosamineinflammationIκBαTNF receptorsTNFα

Identifiers

PMID37373540
PMCPMC10299282
OpenAlexW4381662745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.