Evidence map›Paper›PMID 37373523›Full record

ReviewInternational journal of molecular sciences2023

Harnessing the Potential of Non-Apoptotic Cell Death Processes in the Treatment of Drug-Resistant Melanoma.

Linyinxue Dong, Ceeane Paul Dagoc Vargas, Xuechen Tian, Xiayu Chu, Chenqi Yin, Aloysius Wong, Yixin Yang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Linyinxue DongWenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China.
Ceeane Paul Dagoc VargasCollege of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Xuechen TianWenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China.ORCID 0000-0002-1256-2890
Xiayu ChuCollege of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Chenqi YinCollege of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Aloysius WongWenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China.ORCID 0000-0002-9105-5845
Yixin YangWenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University, Wenzhou 325060, China.ORCID 0000-0001-7997-3849
Wenzhou-Kean University · CN

Funding

Wenzhou Municipal Key Laboratory for Applied Biomedical and the Biopharmaceutical Informat-ics [WB20211227000125]Zhejiang Bioinformatics International Science and Technology Cooperation Center at Wenzhou-Kean University [WB20210429000008]
6 · The paper itself

Abstract

Melanoma is a highly malignant skin cancer that is known for its resistance to treatments. In recent years, there has been significant progress in the study of non-apoptotic cell death, such as pyroptosis, ferroptosis, necroptosis, and cuproptosis. This review provides an overview of the mechanisms and signaling pathways involved in non-apoptotic cell death in melanoma. This article explores the interplay between various forms of cell death, including pyroptosis, necroptosis, ferroptosis, and cuproptosis, as well as apoptosis and autophagy. Importantly, we discuss how these non-apoptotic cell deaths could be targeted as a promising therapeutic strategy for the treatment of drug-resistant melanoma. This review provides a comprehensive overview of non-apoptotic processes and gathers recent experimental evidence that will guide future research and eventually the creation of treatment strategies to combat drug resistance in melanoma.

Indexed as

FerroptosisMelanomaApoptosisCell DeathHumansPyroptosisanti-cancer therapydrug resistancemelanomanon-apoptotic cell death

Identifiers

PMID37373523
PMCPMC10299440
OpenAlexW4381664501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.