Evidence map›Paper›PMID 37373503›Full record

ArticleInternational journal of molecular sciences2023

Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids.

Sara F Vieira, Joana Araújo, Virgínia M F Gonçalves, Carla Fernandes, Madalena Pinto, Helena Ferreira, Nuno M Neves, Maria Elizabeth Tiritan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sara F Vieira3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0001-9158-3114
Joana AraújoLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Virgínia M F GonçalvesTOXRUN-Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal.ORCID 0000-0002-9151-516X
Carla FernandesLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0003-0940-9163
Madalena PintoLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Helena Ferreira3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0002-3770-9393
Nuno M Neves3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0003-3041-0687
Maria Elizabeth TiritanLaboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0003-3320-730X
Universidade do Porto · PTUniversity of Minho · PTCooperativa de Ensino Superior Politécnico e Universitário · PT

Funding

Cooperativa de Ensino Superior Politécnico e Universitário Project XANTAAL-GI2-CESPU-2022 and Flav4Tumor-GI2-CESPU-2022Fundação para a Ciência e Tecnologia PTDC/CTAAMB/6686/2020, and PTDC/CTAAMB/0853/2021Fundação para a Ciência e Tecnologia UIDB/04423/2020 and UIDP/04423/2020HEALTH-UNORTE NORTE-01-0145-FEDER-000039PATH PD/00169/2013PhD grants PD/BD/135246/2017 and COVID/BD/152012/2021the NORTE 2020 Structured Project and co-funded by Norte2020 NORTE-01-0145-FEDER-000021
6 · The paper itself

Abstract

In recent decades, the relationship between drug chirality and biological activity has been assuming enormous importance in medicinal chemistry. Particularly, chiral derivatives of xanthones (CDXs) have interesting biological activities, including enantioselective anti-inflammatory activity. Herein, the synthesis of a library of CDXs is described, by coupling a carboxyxanthone (

Indexed as

Amino AcidsXanthonesAnti-Inflammatory AgentsInterleukin-6StereoisomerismAmino AcidsAnti-Inflammatory AgentsInterleukin-6Xanthonesanti-inflammatory activitychiralitychiral poolenantioselectivityxanthones

Identifiers

PMID37373503
PMCPMC10299275
OpenAlexW4381429263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.