ArticleInternational journal of molecular sciences2023
Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review.Scientific reports · 2025Pooled it
- Pooled it
- Accumulating the key proteomic signatures associated with delirium: Evidence from systematic review.PloS one · 2024Pooled it
- Tranexamic acid use and the risk of postoperative delirium after spine surgery: a retrospective cohort study.BMC anesthesiology · 2026Article
- Quantitative EEG-Based Detection of Poststroke Delirium Endotypes and Their Association With Biomarkers of Inflammation.Brain and behavior · 2026Observational
- Associations between preoperative biomarkers and patient-reported outcomes after single-level lumbar discectomy: a systematic review.Journal of spine surgery (Hong Kong) · 2026Review
- Diagnosis, Prevention, Management, and Prognostication of Delirium in Acute-Care Neurosurgical Patients: A Systematic Scoping Review.Neurocritical care · 2026Review
- Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI.Molecular psychiatry · 2026Observational
- Complement Activation as a Predictor of Postoperative Delirium in Elderly Spine Surgery Patients.International journal of molecular sciences · 2026Article
- Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies.Frontiers in neuroscience · 2026Review
- The relation between postoperative cognitive disorders and brain damage biomarkers after major urologic surgery: a prospective cohort study.Perioperative medicine (London, England) · 2025Article
- Article
- The Role of Cytokines in Perioperative Neurocognitive Disorders: A Review in the Context of Anesthetic Care.Biomedicines · 2025Review
- Longitudinal Assessment of Blood-Based Inflammatory, Neuromuscular, and Neurovascular Biomarker Profiles in Intensive Care Unit-Acquired Weakness: A Prospective Single-Center Cohort Study.Neurocritical care · 2025Observational
- CCL4L2 is a potential biomarker for differentiating central and peripheral vertigo.Frontiers in integrative neuroscience · 2025Article
- Association between perioperative rate pressure product and postoperative delirium in geriatric patients with hip fracture.Frontiers in medicine · 2025Article
- Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery.Frontiers in psychiatry · 2025Article
- The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review.Molecular neurobiology · 2024Review
- Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in spine surgery enable technically safe interventions in older patients with disabling spine disease, yet postoperative delirium (POD) poses a serious risk for postoperative recovery. This study investigates biomarkers of pro-neuroinflammatory states that may help objectively define the pre-operative risk for POD. This study enrolled patients aged ≥60 scheduled for elective spine surgery under general anesthesia. Biomarkers for a pro-neuroinflammatory state included S100 calcium-binding protein β (S100β), brain-derived neurotrophic factor (BDNF), Gasdermin D, and the soluble ectodomain of the triggering receptor expressed on myeloid cells 2 (sTREM2). Postoperative changes of Interleukin-6 (IL-6), Interleukin-1β (IL-1β), and C-reactive protein (CRP) were assessed as markers of systemic inflammation preoperatively, intraoperatively, and early postoperatively (up to 48 h). Patients with POD (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.