Evidence map›Paper›PMID 37373467›Full record

ArticleInternational journal of molecular sciences2023

Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.

Hannah Boeckel, Christian M Karsten, Wolfgang Göpel, Egbert Herting, Jan Rupp, Christoph Härtel, Annika Hartz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hannah BoeckelDepartment of Pediatrics, University of Lübeck, 23538 Lübeck, Germany.
Christian M KarstenInternational Research Training Group 1911, University of Lübeck, 23538 Lübeck, Germany.
Wolfgang GöpelDepartment of Pediatrics, University of Lübeck, 23538 Lübeck, Germany.
Egbert HertingDepartment of Pediatrics, University of Lübeck, 23538 Lübeck, Germany.
Jan RuppInternational Research Training Group 1911, University of Lübeck, 23538 Lübeck, Germany.
Christoph HärtelInternational Research Training Group 1911, University of Lübeck, 23538 Lübeck, Germany.
Annika HartzDepartment of Pediatrics, University of Lübeck, 23538 Lübeck, Germany.
University of Lübeck · DEGerman Center for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm infants are susceptible to infection and their defense against pathogens relies largely on innate immunity. The role of the complement system for the immunological vulnerability of preterm infants is less understood. Anaphylatoxin C5a and its receptors C5aR1 and -2 are known to be involved in sepsis pathogenesis, with C5aR1 mainly exerting pro-inflammatory effects. Our explorative study aimed to determine age-dependent changes in the expression of C5aR1 and C5aR2 in neonatal immune cell subsets. Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n = 32) compared to those of their mothers (n = 25). Term infants and healthy adults served as controls. Preterm infants had a higher intracellular expression of C5aR1 on neutrophils than control individuals. We also found a higher expression of C5aR1 on NK cells, particularly on the cytotoxic CD56

Indexed as

NeutrophilsReceptor, Anaphylatoxin C5aAnaphylatoxinsHumansInfant, NewbornInfant, PrematureKiller Cells, NaturalAnaphylatoxinsReceptor, Anaphylatoxin C5aC5aC5aR1innate immunityneutrophilsNK cellspreterm infantssepsis

Identifiers

PMID37373467
PMCPMC10299388
OpenAlexW4381149295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.