Evidence map›Paper›PMID 37373424›Full record

ReviewInternational journal of molecular sciences2023

Entering, Linked with the Sphinx: Lysophosphatidic Acids Everywhere, All at Once, in the Oral System and Cancer.

D Roselyn Cerutis, Michael D Weston, Takanari Miyamoto

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

D Roselyn CerutisDepartment of Oral Biology, Creighton University School of Dentistry, Omaha, NE 68178, USA.
Michael D WestonDepartment of Oral Biology, Creighton University School of Dentistry, Omaha, NE 68178, USA.
Takanari MiyamotoDepartment of Periodontics, Creighton University School of Dentistry, Omaha, NE 68178, USA.

Funding

The Role of LPA1 in the Etiology of Periodontal DiseaseR15DE028687 · NIDCR · CREIGHTON UNIVERSITY · PI CERUTIS, D. ROSELYN · 2019 to 2019
$431k
LPAR Control of Oral Fibroblast Regenerative ResponsesR15DE016855 · NIDCR · CREIGHTON UNIVERSITY · PI CERUTIS, D. ROSELYN ROSELYN · 2005 to 2005
$214k
NIDCR NIH HHS R15 DE016855NIDCR NIH HHS R15 DE028687NIH HHS 1R15DE16855-01
6 · The paper itself

Abstract

Oral health is crucial to overall health, and periodontal disease (PDD) is a chronic inflammatory disease. Over the past decade, PDD has been recognized as a significant contributor to systemic inflammation. Here, we relate our seminal work defining the role of lysophosphatidic acid (LPA) and its receptors (LPARs) in the oral system with findings and parallels relevant to cancer. We discuss the largely unexplored fine-tuning potential of LPA species for biological control of complex immune responses and suggest approaches for the areas where we believe more research should be undertaken to advance our understanding of signaling at the level of the cellular microenvironment in biological processes where LPA is a key player so we can better treat diseases such as PDD, cancer, and emerging diseases.

Indexed as

NeoplasmsReceptors, Lysophosphatidic AcidHumansInflammationLysophospholipidsSignal TransductionTumor MicroenvironmentLysophospholipidsReceptors, Lysophosphatidic Acidautotaxinbone biologycancerGPCRinflammationlysophosphatidic acidlysophosphatidic acid receptorslysophosphatidic acid speciesMALDI-MSIperiodontal diseasesphingosine-1-phosphate

Identifiers

PMID37373424
PMCPMC10299546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.