Evidence map›Paper›PMID 37373414›Full record

ReviewInternational journal of molecular sciences2023

TGF-β Signaling in Progression of Oral Cancer.

Yuanyuan Guo, Tiansong Xu, Yujuan Chai, Feng Chen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yuanyuan GuoDepartment of Biomedical Engineering, Shenzhen University Medicine School, Shenzhen University, Shenzhen 518060, China.
Tiansong XuCentral Laboratory, Peking University School of Stomatology, Beijing 100081, China.
Yujuan ChaiDepartment of Biomedical Engineering, Shenzhen University Medicine School, Shenzhen University, Shenzhen 518060, China.
Feng ChenCentral Laboratory, Peking University School of Stomatology, Beijing 100081, China.
Peking University · CNShenzhen University · CN

Funding

Guangdong Young Innovative Talents Project 2022KQNCX067Innovation and Entrepreneurship Training Program for College Students 202210590017XNational Key R&D Program of China SQ2022YFE010688Shenzhen Overseas Talent Program 827-000511The National Natural Science Foundation of China No.81991501
6 · The paper itself

Abstract

Oral cancer is a common malignancy worldwide, accounting for 1.9% to 3.5% of all malignant tumors. Transforming growth factor β (TGF-β), as one of the most important cytokines, is found to play complex and crucial roles in oral cancers. It may act in a pro-tumorigenic and tumor-suppressive manner; activities of the former include cell cycle progression inhibition, tumor microenvironment preparation, apoptosis promotion, stimulation of cancer cell invasion and metastasis, and suppression of immune surveillance. However, the triggering mechanisms of these distinct actions remain unclear. This review summarizes the molecular mechanisms of TGF-β signal transduction, focusing on oral squamous cell and salivary adenoid systemic carcinomas as well as keratocystic odontogenic tumors. Both the supporting and contrary evidence of the roles of TGF-β is discussed. Importantly, the TGF-β pathway has been the target of new drugs developed in the past decade, some having demonstrated promising therapeutic effects in clinical trials. Therefore, the achievements of TGF-β pathway-based therapeutics and their challenges are also assessed. The summarization and discussion of the updated knowledge of TGF-β signaling pathways will provide insight into the design of new strategies for oral cancer treatment, leading to an improvement in oral cancer outcomes.

Indexed as

Mouth NeoplasmsTransforming Growth Factor betaCarcinogenesisCytokinesHumansSignal TransductionTumor MicroenvironmentCytokinesTransforming Growth Factor betakeratocystic odontogenic tumorsmechanismoral canceroral squamous cell carcinomassalivary adenoid cystic carcinomaTGF-β signaling pathwaytherapeutics

Identifiers

PMID37373414
PMCPMC10299206
OpenAlexW4381252624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.