Evidence map›Paper›PMID 37373361›Full record

ArticleInternational journal of molecular sciences2023

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.

Alexander V Aksenov, Dmitrii A Aksenov, Igor A Kurenkov, Alexander V Leontiev, Nicolai A Aksenov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Special Issue "Development and Synthesis of Biologically Active Compounds".International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander V AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-6644-9949
Dmitrii A AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-0727-9652
Igor A KurenkovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-0911-4093
Alexander V LeontievDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0003-4742-1999
Nicolai A AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-7125-9066

Funding

Russian Science Foundation 21-73-10029
6 · The paper itself

Abstract

The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.

Indexed as

AldehydesKetonesHumansAldehydesKetones5-hydroxy-3-pyrrolin-2-onescascade transformationschalcones

Identifiers

PMID37373361
PMCPMC10299564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.