Evidence map›Paper›PMID 37373287›Full record

ArticleInternational journal of molecular sciences2023

Less Severe Lipopolysaccharide-Induced Inflammation in Conditional

Wilasinee Saisorn, Pornpimol Phuengmaung, Jiraphorn Issara-Amphorn, Jiradej Makjaroen, Peerapat Visitchanakun, Kritsanawan Sae-Khow, Atsadang Boonmee, Salisa Benjaskulluecha, Aleksandra Nita-Lazar, Tanapat Palaga and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Wilasinee SaisornInterdisciplinary Program of Biomedical Sciences, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-0074-0389
Pornpimol PhuengmaungDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Jiraphorn Issara-AmphornFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892-1892, USA.
Jiradej MakjaroenCenter of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-6025-0106
Peerapat VisitchanakunDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Kritsanawan Sae-KhowDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Atsadang BoonmeeDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Salisa BenjaskulluechaDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Aleksandra Nita-LazarFunctional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892-1892, USA.ORCID 0000-0002-8523-605X
Tanapat PalagaDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Asada LeelahavanichkulDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Chulalongkorn University · THNational Institute of Allergy and Infectious Diseases · US

Funding

Protein Modifications Involved in Cell SignalingZIAAI001084 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NITA-LAZAR, ALEKSANDRA · 2009 to 2025
$11.4M
Program Management Unit for Human Resources, Institutional Development, Research, and In-novation (B16F640175) B16F640175Rachadapisek Sompote Matching Fund RA-MF-22/65 and RA-MF-13/66
6 · The paper itself

Abstract

Despite the known influence of DNA methylation from lipopolysaccharide (LPS) activation, data on the O6-methylguanine-DNA methyltransferase (MGMT, a DNA suicide repair enzyme) in macrophages is still lacking. The transcriptomic profiling of epigenetic enzymes from wild-type macrophages after single and double LPS stimulation, representing acute inflammation and LPS tolerance, respectively, was performed. Small interfering RNA (siRNA) silencing of

Indexed as

LipopolysaccharidesTumor Necrosis Factor-alphaAnimalsDNADNA RepairInflammationIntegrasesInterleukin-6MacrophagesMiceCre recombinaseDNAIntegrasesInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaepigeneticslipopolysaccharidemacrophagesmgmtsepsis

Identifiers

PMID37373287
PMCPMC10299370
OpenAlexW4380995910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.