Evidence map›Paper›PMID 37373173›Full record

ArticleInternational journal of molecular sciences2023

Apoptosis Related Human Wharton's Jelly-Derived Stem Cells Differentiation into Osteoblasts, Chondrocytes, Adipocytes and Neural-like Cells-Complete Transcriptomic Assays.

Katarzyna Stefańska, Lucie Nemcova, Małgorzata Blatkiewicz, Wojciech Pieńkowski, Marcin Ruciński, Maciej Zabel, Paul Mozdziak, Marzenna Podhorska-Okołów, Piotr Dzięgiel, Bartosz Kempisty

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Katarzyna StefańskaDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0002-8814-4935
Lucie NemcovaInstitute of Animal Physiology and Genetics of the Czech Academy of Sciences, 27721 Libechov, Czech Republic.ORCID 0000-0002-2594-3369
Małgorzata BlatkiewiczDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0001-5506-2397
Wojciech PieńkowskiDivision of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Marcin RucińskiDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0002-2525-5777
Maciej ZabelDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Paul MozdziakPrestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-1575-3123
Marzenna Podhorska-OkołówDivision of Ultrastructural Research, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0002-8292-1385
Bartosz KempistyDepartment of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland.
Poznan University of Medical Sciences · PLWroclaw Medical University · PLNorth Carolina State University · USCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZ

Funding

Ministry of Education Youth and Sports CZ.02.1.01/0.0/0.0/15_003/0000460Ministry of Science and Higher Education 0070/DW/2018/02
6 · The paper itself

Abstract

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit multilineage differentiation potential, adhere to plastic, and express a specific set of surface markers-CD105, CD73, CD90. Although there are relatively well-established differentiation protocols for WJ-MSCs, the exact molecular mechanisms involved in their in vitro long-term culture and differentiation remain to be elucidated. In this study, the cells were isolated from Wharton's jelly of umbilical cords obtained from healthy full-term deliveries, cultivated in vitro, and differentiated towards osteogenic, chondrogenic, adipogenic and neurogenic lineages. RNA samples were isolated after the differentiation regimen and analyzed using an RNA sequencing (RNAseq) assay, which led to the identification of differentially expressed genes belonging to apoptosis-related ontological groups.

Indexed as

Mesenchymal Stem CellsWharton JellyAdipocytesApoptosisCell DifferentiationCells, CulturedChondrocytesHumansNerve Tissue ProteinsOsteoblastsTranscriptomeBEX2 protein, humanNerve Tissue Proteinsapoptosisdifferentiationmesenchymal stem cellsMSCRNAseqWharton’s jelly

Identifiers

PMID37373173
PMCPMC10297881
OpenAlexW4380486468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.