Evidence map›Paper›PMID 37373172›Full record

ArticleInternational journal of molecular sciences2023

Comprehensive Analysis of Circular RNAs in Endothelial Cells.

Sabina Lichołai, Dorota Studzińska, Hanna Plutecka, Tomasz Gubała, Marek Sanak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The role of miRNAs in Behçet's disease.Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sabina LichołaiDivision of Molecular Biology and Clinical Genetics, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Dorota StudzińskaDepartment of Intensive Care and Perioperative Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-901 Krakow, Poland.
Hanna PluteckaDivision of Molecular Biology and Clinical Genetics, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Tomasz GubałaSano-Centre for Computational Medicine, 30-072 Krakow, Poland.
Marek SanakDivision of Molecular Biology and Clinical Genetics, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.ORCID 0000-0001-7635-8103
Jagiellonian University · PL

Funding

National Center of Science, Poland 2016/21/N/NZ2/01735
6 · The paper itself

Abstract

Non-coding RNAs constitute a heterogeneous group of molecules that lack the ability to encode proteins but retain the potential ability to influence cellular processes through a regulatory mechanism. Of these proteins, microRNAs, long non-coding RNAs, and more recently, circular RNAs have been the most extensively described. However, it is not entirely clear how these molecules interact with each other. For circular RNAs, the basics of their biogenesis and properties are also lacking. Therefore, in this study we performed a comprehensive analysis of circular RNAs in relation to endothelial cells. We identified the pool of circular RNAs present in the endothelium and showed their spectrum and expression across the genome. Using different computational strategies, we proposed approaches to search for potentially functional molecules. In addition, using data from an in vitro model that mimics conditions in the endothelium of an aortic aneurysm, we demonstrated altered expression levels of circRNAs mediated by microRNAs.

Indexed as

MicroRNAsRNA, Long NoncodingEndothelial CellsRNA, CircularMicroRNAsRNA, CircularRNA, Long Noncodingcircular RNAsendothelial cellsepigenetic regulation

Identifiers

PMID37373172
PMCPMC10298487
OpenAlexW4380486480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.