Evidence map›Paper›PMID 37373144›Full record

ArticleInternational journal of molecular sciences2023

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation.

Phuc-Tan Nguyen, Yuki Nakamura, Nguyen Quoc Vuong Tran, Kayoko Ishimaru, Thuy-An Nguyen, Yoshiaki Kobayashi, Fumie Watanabe-Saito, Tohru Okuda, Nobuhiro Nakano, Atsuhito Nakao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Phuc-Tan NguyenDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0009-0006-0045-6317
Yuki NakamuraDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-5750-6921
Nguyen Quoc Vuong TranDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0003-4038-2704
Kayoko IshimaruDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-6755-3203
Thuy-An NguyenDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Yoshiaki KobayashiDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Fumie Watanabe-SaitoThe Institute of Enology and Viticulture, University of Yamanashi, Yamanashi 400-0005, Japan.
Tohru OkudaThe Institute of Enology and Viticulture, University of Yamanashi, Yamanashi 400-0005, Japan.
Nobuhiro NakanoAtopy Research Center, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-5317-5950
Atsuhito NakaoDepartment of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
University of Yamanashi · JPJuntendo University · JP

Funding

The ministry of education, culture, sports, science and technology, Japan 22K19427
6 · The paper itself

Abstract

Ethyl caffeate (EC) is a natural phenolic compound that is present in several medicinal plants used to treat inflammatory disorders. However, its anti-inflammatory mechanisms are not fully understood. Here, we report that EC inhibits aryl hydrocarbon receptor (AhR) signaling and that this is associated with its anti-allergic activity. EC inhibited AhR activation, induced by the AhR ligands FICZ and DHNA in AhR signaling-reporter cells and mouse bone marrow-derived mast cells (BMMCs), as assessed by AhR target gene expressions such as

Indexed as

Mast CellsReceptors, Aryl HydrocarbonAnimalsAnti-Inflammatory AgentsAzo CompoundsCaffeic AcidsCytochrome P-450 CYP1A1LigandsMicePyrazoles2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amideAnti-Inflammatory AgentsAzo CompoundsCaffeic AcidsCytochrome P-450 CYP1A1ethyl caffeateLigandsPyrazolesReceptors, Aryl Hydrocarbonallergyaryl hydrocarbon receptorethyl caffeateIgEmast cell

Identifiers

PMID37373144
PMCPMC10297944
OpenAlexW4380361429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.