Evidence map›Paper›PMID 37373129›Full record

ArticleInternational journal of molecular sciences2023

QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders.

Mohammed Ghazwani, Mohammed H Alqarni, Umme Hani, Aftab Alam

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mohammed GhazwaniDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, P.O. Box 1882, Abha 61441, Saudi Arabia.ORCID 0000-0003-3555-4268
Mohammed H AlqarniDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.ORCID 0000-0002-7061-9111
Umme HaniDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, P.O. Box 1882, Abha 61441, Saudi Arabia.ORCID 0000-0003-4643-0922
Aftab AlamDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.ORCID 0000-0001-6733-8311
King Khalid University · SAPrince Sattam Bin Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, elastic nanovesicles, constructed of phospholipids optimized by Quality by Design (QbD), release 6-gingerol (6-G), a natural chemical that may alleviate osteoporosis and musculoskeletal-related pain. A 6-gingerol-loaded transfersome (6-GTF) formulation was developed using a thin film and sonication approach. 6-GTFs were optimized using BBD. Vesicle size, PDI, zeta potential, TEM,

Indexed as

Drug CarriersPhospholipidsAdministration, CutaneousAntioxidantsCatecholsFatty AlcoholsHumansPainParticle SizeSkinAntioxidantsCatecholsDrug CarriersFatty AlcoholsgingerolPhospholipids6-gingerolantioxidantBox–Behnken designconfocal laser scanning microscopymusculoskeletal disorderosteoporosistransfersomes

Identifiers

PMID37373129
PMCPMC10298657
OpenAlexW4380321751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.