Evidence map›Paper›PMID 37373114›Full record

ArticleInternational journal of molecular sciences2023

New 3-Aminopropylsilatrane Derivatives: Synthesis, Structure, Properties, and Biological Activity.

Sergey N Adamovich, Igor A Ushakov, Elizaveta N Oborina, Svetlana V Lukyanova, Vladislav Y Komarov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sergey N AdamovichA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Igor A UshakovA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Elizaveta N OborinaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Svetlana V LukyanovaIrkutsk Antiplague Research Institute of Siberia and Far East, 78 Trilisser Street, 664047 Irkutsk, Russia.
Vladislav Y KomarovA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Prospekt, 630090 Novosibirsk, Russia.
A.E. Favorsky Irkutsk Institute of Chemistry · RUIrkutsk Antiplague Research Institute of Siberia and Far East · RUNikolaev Institute of Inorganic Chemistry · RU

Funding

Russian Science Foundation 23-26-10007
6 · The paper itself

Abstract

The biologically active compound 3-aminopropylsilatrane (a compound with a pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates and other Michael acceptors. Depending on the molar ratio, the reaction yielded Michael mono- or diadducts (11 examples) containing functional groups (silatranyl, carbonyl, nitrile, amino, etc.). These compounds were characterized via IR and NMR spectroscopy, mass spectrometry, X-ray diffraction, and elemental analysis. Calculations (using in silico, PASS, and SwissADMET online software) revealed that the functionalized (hybrid) silatranes were bioavailable, druglike compounds that exhibited pronounced antineoplastic and macrophage-colony-stimulating activity. The in vitro effect of silatranes on the growth of pathogenic bacteria (

Indexed as

Antineoplastic AgentsOrganosilicon CompoundsBridged Bicyclo Compounds, HeterocyclicMass SpectrometryMolecular StructureX-Ray DiffractionAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicOrganosilicon Compoundssilatrane3-aminopropylsilatraneacrylatesaza-Michael reactionbiological activitymono- and diadducts

Identifiers

PMID37373114
PMCPMC10298438
OpenAlexW4380082075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.