Evidence map›Paper›PMID 37373059›Full record

ReviewInternational journal of molecular sciences2023

Interactome of Long Non-Coding RNAs: Transcriptomic Expression Patterns and Shaping Cancer Cell Phenotypes.

Nicole R DeSouza, Danielle Quaranto, Michelle Carnazza, Tara Jarboe, Raj K Tiwari, Jan Geliebter

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicole R DeSouzaDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Danielle QuarantoDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Michelle CarnazzaDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Tara JarboeDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0009-0000-4973-0686
Raj K TiwariDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
Jan GeliebterDepartment of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0000-0002-2944-7960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA biology has gained extensive recognition in the last two decades due to the identification of novel transcriptomic elements and molecular functions. Cancer arises, in part, due to the accumulation of mutations that greatly contribute to genomic instability. However, the identification of differential gene expression patterns of wild-type loci has exceeded the boundaries of mutational study and has significantly contributed to the identification of molecular mechanisms that drive carcinogenic transformation. Non-coding RNA molecules have provided a novel avenue of exploration, providing additional routes for evaluating genomic and epigenomic regulation. Of particular focus, long non-coding RNA molecule expression has been demonstrated to govern and direct cellular activity, thus evidencing a correlation between aberrant long non-coding RNA expression and the pathological transformation of cells. lncRNA classification, structure, function, and therapeutic utilization have expanded cancer studies and molecular targeting, and understanding the lncRNA interactome aids in defining the unique transcriptomic signatures of cancer cell phenotypes.

Indexed as

NeoplasmsRNA, Long NoncodingGene Expression ProfilingHumansTranscriptomeRNA, Long NoncodingcancercircRNAdevelopmental defectsdisease pathogenesislncRNAmicroRNAnoncoding RNApiRNA

Identifiers

PMID37373059
PMCPMC10298192

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.