Evidence map›Paper›PMID 37373041›Full record

ArticleInternational journal of molecular sciences2023

IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells.

Roberto Riquelme-Neira, Romina Walker-Vergara, Joan Antoni Fernández-Blanco, Patrocinio Vergara

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Roberto Riquelme-NeiraNúcleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronómicas, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Sede Concepción, Chacabuco 539, Concepción 4070254, Chile.ORCID 0000-0002-0518-5556
Romina Walker-VergaraNúcleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronómicas, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Sede Concepción, Chacabuco 539, Concepción 4070254, Chile.
Joan Antoni Fernández-BlancoDepartment of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.ORCID 0000-0002-1788-4928
Patrocinio VergaraDepartment of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Universitat Autònoma de Barcelona · ESUniversity of the Americas · CL

Funding

CONICYT Doctorado Becas Chile from Ministerio de Educación, Comisión Nacional de Investigación Científica y Tecnológica 72150119Generalitat de Catalunya 2014SGR789
6 · The paper itself

Abstract

Mast cells (MCs) are involved in several immune-related responses, including those in bacterial infections, autoimmune diseases, inflammatory bowel diseases, and cancer, among others. MCs identify microorganisms by pattern recognition receptors (PRRs), activating a secretory response. Interleukin (IL)-10 has been described as an important modulator of MC responses; however, its role in PRR-mediated activation of MC is not fully understood. We analyzed the activation of TLR2, TLR4, TLR7 and Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) in mucosal-like MCs (MLMCs) and peritoneum-derived cultured MCs (PCMCs) from IL-10

Indexed as

Interleukin-10Interleukin-6AnimalsCytokinesLigandsMast CellsMiceNod2 Signaling Adaptor ProteinReceptors, Pattern RecognitionToll-Like Receptor 2Toll-Like Receptor 4Toll-Like Receptor 7CytokinesIL10 protein, mouseInterleukin-10Interleukin-6LigandsNod2 Signaling Adaptor ProteinReceptors, Pattern RecognitionToll-Like Receptor 2Toll-Like Receptor 4Toll-Like Receptor 7interleukin-10MMCNOD2PCMCPRRTLR

Identifiers

PMID37373041
PMCPMC10298310
OpenAlexW4379882055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.