The Phosphoproteome of the Rd1 Mouse Retina, a Model of Inherited Photoreceptor Degeneration, Changes after Protein Kinase G Inhibition.

Jiaming Zhou, Charlotte Welinder, Per Ekström

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Integrative Kinase Activity Profiling and Phosphoproteomics ofInternational journal of molecular sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jiaming ZhouOphthalmology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, 221 00 Lund, Sweden.ORCID 0000-0002-0043-3645

Charlotte WelinderMass Spectrometry, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, 221 00 Lund, Sweden.ORCID 0000-0001-9626-0576

Per EkströmOphthalmology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, 221 00 Lund, Sweden.

Lund University · SE

Funding

Carmen och Bertil Regnérs Stiftelse för forskning inom området ögonsjukdomar NoEuropean Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement transMed; H2020-MSCA-765441Kronprinsessan Margaretas Arbetsnämnd för synskadade NoÖgonfonden NoStiftelsen för Synskadade i f.d. Malmöhus län NoThe Stiftelsen Hedda och John Forssmans No 40642

6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is a frequent cause of blindness among the working population in industrial countries due to the inheritable death of photoreceptors. Though gene therapy was recently approved for mutations in the RPE65 gene, there is in general no effective treatment presently. Previously, abnormally high levels of cGMP and overactivation of its dependent protein kinase (PKG) have been suggested as causative for the fatal effects on photoreceptors, making it meaningful to explore the cGMP-PKG downstream signaling for more pathological insights and novel therapeutic target development purposes. Here, we manipulated the cGMP-PKG system in degenerating retinas from the

Indexed as

Retinal DegenerationRetinitis PigmentosaAnimalsCyclic GMP-Dependent Protein KinasesMiceRetinaSignal TransductionCyclic GMP-Dependent Protein Kinasesmass spectrometryorganotypic retinal explant culturephosphoproteomeretinal degeneration

Identifiers

PMID37372984

DOI10.3390/ijms24129836

PMCPMC10298292

OpenAlexW4379796092

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.