Evidence map›Paper›PMID 37372979›Full record

ArticleInternational journal of molecular sciences2023

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

Yao-Jen Chang, Steven Lin, Zhi-Fu Kang, Bin-Jon Shen, Wen-Hai Tsai, Wen-Ching Chen, Hsin-Pin Lu, Yu-Lun Su, Shu-Jen Chou, Shu-Yu Lin and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Multifaceted role ofMedComm · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Yao-Jen ChangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-1985-2428
Steven LinInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-7542-4663
Zhi-Fu KangGraduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Bin-Jon ShenInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Wen-Hai TsaiInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Wen-Ching ChenGraduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Hsin-Pin LuGraduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
Yu-Lun SuInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-3803-6047
Shu-Jen ChouInstitute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan.
Shu-Yu LinInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Sheng-Wei LinInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Yin-Jung HuangDepartment of Pediatrics, Division of Pediatric Immunology and Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Hsin-Hui WangDepartment of Pediatrics, Division of Pediatric Immunology and Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Ching-Jin ChangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
National Taiwan University · TWInstitute of Biological Chemistry, Academia Sinica · TWInstitute of Plant and Microbial Biology, Academia Sinica · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

Academia Sinica 034004Ministry of Science and Technology 107-2314-B-075-036 and 108-2314-B-075-043-MY2Taipei Veterans General Hospital V105C-179, V106C-180, and V107C-176
6 · The paper itself

Abstract

TRIM28/KAP1/TIF1β is a crucial epigenetic modifier. Genetic ablation of

Indexed as

Protein Processing, Post-TranslationalRepressor ProteinsAcetylationGene ExpressionHumansK562 CellsMutationTripartite Motif-Containing Protein 28ZincRepressor ProteinsTRIM28 protein, humanTripartite Motif-Containing Protein 28ZincacetylationCRISPR/Cas9K562KRAB-ZNFTRIM28

Identifiers

PMID37372979
PMCPMC10298087
OpenAlexW4379792816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.