Evidence map›Paper›PMID 37372935›Full record

ArticleInternational journal of molecular sciences2023

Cm-p5 Peptide Dimers Inhibit Biofilms of

Valerie Amann, Ann-Kathrin Kissmann, Vanessa Mildenberger, Imke Krebs, Julio A Perez-Erviti, Ernesto M Martell-Huguet, Anselmo J Otero-Gonzalez, Fidel Morales-Vicente, Gina P Rodríguez-Castaño, Carolina Firacative and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  7. Unveiling the mechanisms of synthetic compounds againstCurrent research in pharmacology and drug discovery · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Valerie AmannInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Ann-Kathrin KissmannInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Vanessa MildenbergerInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Imke KrebsInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0009-0007-5885-4112
Julio A Perez-ErvitiCenter for Protein Studies, Faculty of Biology, University of Havana, 25 Str. and I Str., La Habana 10400, Cuba.ORCID 0000-0003-2635-8767
Ernesto M Martell-HuguetCenter for Protein Studies, Faculty of Biology, University of Havana, 25 Str. and I Str., La Habana 10400, Cuba.
Anselmo J Otero-GonzalezCenter for Protein Studies, Faculty of Biology, University of Havana, 25 Str. and I Str., La Habana 10400, Cuba.ORCID 0000-0002-1719-0117
Fidel Morales-VicenteSynthetic Peptides Group, Center for Genetic Engineering and Biotechnology, La Habana 10600, Cuba.
Gina P Rodríguez-CastañoVidarium Nutrition, Health and Wellness Research Center, Grupo Nutresa, Calle 8 sur #50-67, Medellín 050023, Colombia.
Carolina FiracativeStudies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health Sciences, Universidad de Rosario, Bogota 111221, Colombia.ORCID 0000-0001-7547-5172
Armando RodríguezCore Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), Faculty of Medicine, Ulm University, 89081 Ulm, Germany.ORCID 0000-0001-5921-3770
Ludger StändkerCore Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), Faculty of Medicine, Ulm University, 89081 Ulm, Germany.ORCID 0000-0002-8436-4260
Tanja WeilMax Planck Institute for Polymer Research Mainz, Ackermannweg 10, 55128 Mainz, Germany.
Barbara SpellerbergInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, 89081 Ulm, Germany.ORCID 0000-0001-7552-8764
Steffen StengerInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, 89081 Ulm, Germany.
Frank RosenauInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0002-9297-6419
Universität Ulm · DEUniversity Hospital Ulm · DEUniversity of Havana · CUCentro de Ingeniería Genética y Biotecnología · CUMax Planck Institute for Polymer Research · DEUniversidad del Rosario · COVidarium - Centro de Investigación en Nutrición Salud y Bienestar

Funding

Alexander von Humboldt Foundation 1160914 - COL - IPBaden-Württemberg Stiftung BiofMO_005 and MIKROBIOM: ID23 AMDADeutsche Forschungsgemeinschaft 316249678-SFB 1279 and 465229237German Academic Exchange Service 57592717-GLACIERHorizon 2020 686271
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) represent a promising class of therapeutic biomolecules that show antimicrobial activity against a broad range of microorganisms, including life-threatening pathogens. In contrast to classic AMPs with membrane-disrupting activities, new peptides with a specific anti-biofilm effect are gaining in importance since biofilms could be the most important way of life, especially for pathogens, as the interaction with host tissues is crucial for the full development of their virulence in the event of infection. Therefore, in a previous study, two synthetic dimeric derivatives (parallel Dimer 1 and antiparallel Dimer 2) of the AMP Cm-p5 showed specific inhibition of the formation of

Indexed as

Candida albicansFluconazoleAntifungal AgentsBiofilmsCandidaCandida parapsilosisMicrobial Sensitivity TestsPeptidesAntifungal AgentsFluconazolePeptidesantimicrobial peptidesbiofilm inhibitionCandida speciesclinical isolatesresistances

Identifiers

PMID37372935
PMCPMC10298552
OpenAlexW4379519693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.