Evidence map›Paper›PMID 37372540›Full record

ArticleFoods (Basel, Switzerland)2023

Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration.

Junxi Fu, Wentian Song, Xiaobing Song, Li Fang, Xiyan Wang, Yue Leng, Ji Wang, Chunlei Liu, Weihong Min

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Junxi FuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Wentian SongCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Xiaobing SongZhongke Special Food Institute, Changchun 130022, China.
Li FangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Xiyan WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0002-5062-7077
Yue LengCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Ji WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0002-3603-4670
Chunlei LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Weihong MinCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
National Engineering Research Center for Wheat · CN

Funding

Natural Science Foundation of Jilin Province 20200201145JC
6 · The paper itself

Abstract

This work aimed to investigate whether there are synergistic effects between walnut peptide (WNP) and ginseng extracts (GSE) treatments to ameliorate the memory impairment caused by scopolamine (SCOP). The Morris water maze trial, hippocampal neuron morphology, neurotransmitters, and synaptic ultrastructure were examined, along with brain-derived neurotrophic factor (BDNF)-related signaling pathway proteins. The results of the Morris water maze trial demonstrated that the combined administration of WNP and GSE effectively alleviated memory impairment in C57BL/6 rats caused by SCOP. Improvement in the morphology of hippocampal neurons, dendritic spines, and synaptic plasticity and upregulation of neurotransmitters AChE, ACh, ChAT, Glu, DA, and 5-HT supported the memory improvement effects of WNP + GSE. In addition, compared with the model group, WNP + GSE significantly enhanced the protein levels of VAChT, Trx-1, and the CREB/BDNF/TrkB pathway in hippocampal and PC12 cells induced by SCOP (

Indexed as

ginseng extractshippocampusmemory improvementneurotransmittersynergistic effectwalnut peptide

Identifiers

PMID37372540
PMCPMC10297067
OpenAlexW4379985370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.