Evidence map›Paper›PMID 37372449›Full record

ArticleGenes2023

Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study.

Carlo Alviggi, Salvatore Longobardi, Enrico Papaleo, Daniele Santi, Simona Alfano, Valeria Stella Vanni, Maria Rosaria Campitiello, Pasquale De Rosa, Ida Strina, Ilpo Huhtaniemi and 4 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Pharmacogenomic of LH and its receptor: are we ready for clinical practice?Reproductive biology and endocrinology : RB&E · 2025
    Review
  4. Observational
  5. Article
  6. Significance ofInternational journal of reproductive biomedicine · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Carlo AlviggiDepartment of Public Health, University of Naples Federico II, Via Sergio Pansini, 80131 Naples, Italy.
Salvatore LongobardiMerck Serono S.p.A., 00176 Rome, Italy.
Enrico PapaleoIRCCS San Raffaele Hospital, 00163 Milan, Italy.
Daniele SantiUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy.ORCID 0000-0001-6607-7105
Simona AlfanoDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Via Sergio Pansini, 80131 Naples, Italy.
Valeria Stella VanniIRCCS San Raffaele Hospital, 00163 Milan, Italy.ORCID 0000-0002-6539-7294
Maria Rosaria CampitielloDepartment of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno, 84124 Salerno, Italy.
Pasquale De RosaAzienda Ospedaliera Universitaria Federico II di Napoli, 80131 Naples, Italy.
Ida StrinaDepartment of Public Health, University of Naples Federico II, Via Sergio Pansini, 80131 Naples, Italy.
Ilpo HuhtaniemiFaculty of Medicine, Department of Surgery and Cancer, London W12 0NN, UK.
Juha-Pekka PursiheimoInstitute of Biomedicine, University of Turku, 20014 Turku, Finland.
Thomas D'HoogheDepartment of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Peter HumaidanFertility Clinic at Skive Regional Hospital, Faculty of Health, Aarhus University, 8000 Aarhus, Denmark.
Alessandro ConfortiDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Via Sergio Pansini, 80131 Naples, Italy.ORCID 0000-0002-5676-0055
Federico II University Hospital · ITUniversity of Naples Federico II · ITVita-Salute San Raffaele University · ITAarhus University · DKKU Leuven · BEMerck Serono (Italy) · ITUniversity of Modena and Reggio Emilia · ITUniversity of Salerno · ITUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpecific polymorphisms might influence controlled ovarian stimulation in women undergoing assisted reproductive technologies (ARTs). Data regarding possible interactions of these polymorphisms are still scanty. The aim of this analysis was to evaluate the effect of polymorphisms of gonadotropins and their receptors in women undergoing ART.

methodsA total of 94 normogonadotropic patients from three public ART units were enrolled. Patients underwent a gonadotropin releasing hormone (GnRH) long down-regulation protocol with a starting dose of 150 IU of recombinant follicular stimulating hormone (FSH) daily. Eight polymorphisms were genotyped.

resultsA total of 94 women (mean age 30.71 ± 2.61) were recruited. Fewer fertilized and mature oocytes were retrieved in homozygous carriers of luteinizing hormone/choriogonadotropin receptor (LHCGR) 291 (T/T) than in heterozygous C/T carriers (

conclusionsOur study demonstrated that specific polymorphisms affect the response to ovarian stimulation. Despite this finding, more robust studies are required to establish the clinical utility of genotype analysis before ovarian stimulation.

Indexed as

Follicle Stimulating HormoneGonadotropinsAnimalsFemaleFertilization in VitroOvulation InductionProspective StudiesFollicle Stimulating HormoneGonadotropinsARTgenetic variantsgonadotropinIVFovarian stimulationpolymorphism

Identifiers

PMID37372449
PMCPMC10298688
OpenAlexW4380987216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.