ArticleGenes2023
Deciphering the Immunostimulatory Effects of β-Glucan on a Rainbow Trout (
Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Functional Feeds as Immunostimulants for Aquaculture: A Molecular Perspective.Aquaculture nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-glucans are a commonly used immunostimulant/prebiotic in many aquaculture applications for boosting the immune status in fish. However, the method of action as an immunostimulant has not been fully deciphered. To determine the immunomodulatory effects of β-glucans on the innate immune response, we stimulated the rainbow trout spleen macrophage-like cell line (RTS11) with β-1,3/1,6-glucans for 4 h. This study uses a whole transcriptomic approach to analyse the immunomodulatory properties of β-glucans. Several proinflammatory pathways were found to be enriched after stimulation, demonstrating the immunomodulatory effects of β-glucan supplementation. Several pathways relating to responses to bacteria were also found to be enriched. This study clearly demonstrates the immunomodulatory effects of the supplementation of β-glucans within an aquaculture setting and further validates the use of cell lines as predictive models to interpret the responses caused by dietary intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.