Evidence map›Paper›PMID 37372414›Full record

ArticleGenes2023

Divergent Transcriptomic Effects of Allopregnanolone in Postpartum Depression.

Sarah A Rudzinskas, Maria A Mazzu, Crystal Edler Schiller, Samantha Meltzer-Brody, David R Rubinow, Peter J Schmidt, David Goldman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah A RudzinskasBehavioral Endocrinology Branch, National Institute of Mental Health (NIMH), NIH, 10 Center Drive MSC 1277, Bethesda, MD 20892, USA.
Maria A MazzuBehavioral Endocrinology Branch, National Institute of Mental Health (NIMH), NIH, 10 Center Drive MSC 1277, Bethesda, MD 20892, USA.
Crystal Edler SchillerDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
Samantha Meltzer-BrodyDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
David R RubinowDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
Peter J SchmidtBehavioral Endocrinology Branch, National Institute of Mental Health (NIMH), NIH, 10 Center Drive MSC 1277, Bethesda, MD 20892, USA.
David GoldmanLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Rockville, MD 20855, USA.
National Institute of Mental Health · USUniversity of North Carolina at Chapel Hill · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
Reproductive Endocrine Related Mood Disorders-Differential SensitivityZIAMH002865 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SCHMIDT, PETER · 2009 to 2025
$11.9M
Neuroendocrine Mechanisms of Reproductive Hormone Related Affective DysfunctionR21MH101409 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBINOW, DAVID R., SCHILLER, CRYSTAL EDLER · 2013 to 2014
$418k
Intramural NIH HHS ZIA AA000301Intramural NIH HHS ZIA MH002865NIH HHS R21MH101409NIH HHS ZIAAA000301NIH HHS ZIAMH002865NIMH NIH HHS R21 MH101409
6 · The paper itself

Abstract

Brexanolone, a formulation of the neurosteroid allopregnanolone (ALLO), is approved for treating postpartum depression (PPD) and is being investigated for therapeutic efficacy across numerous neuropsychiatric disorders. Given ALLO's beneficial effects on mood in women with PPD compared to healthy control women, we sought to characterize and compare the cellular response to ALLO in women with (

Indexed as

Depression, PostpartumPregnanoloneAntidepressive AgentsDimethyl SulfoxideFemaleHumansTranscriptomeAntidepressive AgentsDimethyl SulfoxidePregnanoloneallopregnanoloneGAD1neurosteroidspostpartum depressiontranscriptomics

Identifiers

PMID37372414
PMCPMC10298697
OpenAlexW4380082151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.