Evidence map›Paper›PMID 37372326›Full record

ArticleGenes2023

Potential Prognostic Value of GATA4 Depends on the p53 Expression in Primary Glioblastoma Patients.

Berenika Trąbska-Kluch, Marcin Braun, Magdalena Orzechowska, Sylwia Paszek, Alina Zuchowska, Julia Sołek, Adam Kluska, Jacek Fijuth, Dorota Jesionek-Kupnicka, Izabela Zawlik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Berenika Trąbska-KluchDepartment of Teleradiotherapy, Copernicus Memorial Hospital, 93-513 Lodz, Poland.
Marcin BraunDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 93-513 Lodz, Poland.ORCID 0000-0003-3804-7042
Magdalena OrzechowskaDepartment of Molecular Carcinogenesis, Medical University of Lodz, 93-513 Lodz, Poland.ORCID 0000-0002-8301-8059
Sylwia PaszekLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.ORCID 0000-0002-7865-2661
Alina ZuchowskaLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.
Julia SołekDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 93-513 Lodz, Poland.
Adam KluskaBrachytherapy Department, Greater Poland Cancer Centre, 61-866 Poznan, Poland.
Jacek FijuthDepartment of Teleradiotherapy, Copernicus Memorial Hospital, 93-513 Lodz, Poland.
Dorota Jesionek-KupnickaDepartment of Pathology, Chair of Oncology, Medical University of Lodz, 93-513 Lodz, Poland.
Izabela ZawlikLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.
Medical University of Lodz · PLUniversity of Rzeszów · PLCopernicus Memorial Hospital · PLGreater Poland Cancer Center · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary glioblastoma is characterized by an extremely poor prognosis. The promoter methylation of MATERIALS AND

methodsThirty-one patients with primary glioblastoma were included. GATA4 and p53 expressions were determined immunohistochemically, and

resultsThe prognostic value of GATA4 depends on p53 expression. Patients without GATA4 protein expression were more frequently negative for

conclusionsOur data indicate that there is a possibility that GATA4 could function as a prognostic factor in glioblastoma patients, but in connection with p53 expression. A lack of GATA4 expression is not dependent on

Indexed as

AstrocytomaGlioblastomaDNA MethylationGATA4 Transcription FactorHumansPrognosisTumor Suppressor Protein p53GATA4 protein, humanGATA4 Transcription FactorTP53 protein, humanTumor Suppressor Protein p53GATA4 promoter methylationGATA4 protein expressionglioblastomaTP53 abnormalities

Identifiers

PMID37372326
PMCPMC10298403
OpenAlexW4378471545

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.