Evidence map›Paper›PMID 37372124›Full record

ArticleBiology2023

Targeted Central Nervous System Irradiation with Proton Microbeam Induces Mitochondrial Changes in

Ahmad Sleiman, Kévin Lalanne, François Vianna, Yann Perrot, Myriam Richaud, Tanima SenGupta, Mikaël Cardot-Martin, Pascal Pedini, Christophe Picard, Hilde Nilsen and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ahmad SleimanInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LMDN, Cadarache, 13115 Saint-Paul-lez-Durance, France.
Kévin LalanneInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LMDN, Cadarache, 13115 Saint-Paul-lez-Durance, France.
François ViannaInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LMDN, Cadarache, 13115 Saint-Paul-lez-Durance, France.ORCID 0000-0002-1326-8140
Yann PerrotInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LDRI, 92262 Fontenay-aux-Roses, France.ORCID 0000-0001-9043-5857
Myriam RichaudIBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0002-7720-8569
Tanima SenGuptaSection of Clinical Molecular Biology (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway.
Mikaël Cardot-MartinInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LMDN, Cadarache, 13115 Saint-Paul-lez-Durance, France.
Pascal PediniAix Marseille University, CNRS, EFS, ADES, 13288 Marseille, France.ORCID 0000-0001-9299-3705
Christophe PicardAix Marseille University, CNRS, EFS, ADES, 13288 Marseille, France.
Hilde NilsenSection of Clinical Molecular Biology (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway.
Simon GalasIBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France.ORCID 0000-0002-1717-1266
Christelle Adam-GuillerminInstitut de Radioprotection et de Sûreté Nucléaire, IRSN, PSE-SANTE/SDOS/LMDN, Cadarache, 13115 Saint-Paul-lez-Durance, France.
Institut de Radioprotection et de Sûreté Nucléaire · FRCentre National de la Recherche Scientifique · FRÉcole Nationale Supérieure de Chimie de Montpellier · FRAkershus University Hospital · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fifty percent of all patients with cancer worldwide require radiotherapy. In the case of brain tumors, despite the improvement in the precision of radiation delivery with proton therapy, studies have shown structural and functional changes in the brains of treated patients with protons. The molecular pathways involved in generating these effects are not completely understood. In this context, we analyzed the impact of proton exposure in the central nervous system area of

Indexed as

C. elegansion microbeammitochondrianervous systemprotonproton therapy

Identifiers

PMID37372124
PMCPMC10295778
OpenAlexW4379985044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.