Evidence map›Paper›PMID 37371988›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice.

Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Gonçalves da Silva, Flávio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valença and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Microorganisms · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Maria Clara Barbosa-de-OliveiraMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.
Paolo Oliveira-MeloLaboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo, Sao Paulo 05508-220, Brazil.
Marcos Henrique Gonçalves da SilvaDepartment of Clinical Medicine, Federal Fluminense University (UFF), Niterói 24000-000, Brazil.
Flávio Santos da SilvaMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.ORCID 0000-0002-7019-0482
Felipe Andrade Carvalho da SilvaMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.
Bruno Vinicios Silva de AraujoMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.ORCID 0000-0003-1964-4706
Moacir Franco de OliveiraDepartment of Animal Science, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.
Aristides Tadeu CorreiaLaboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo, Sao Paulo 05508-220, Brazil.
Sidnei Miyoshi SakamotoMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.ORCID 0000-0003-4116-0388
Samuel Santos ValençaInstitute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-1868-9905
Manuella LanzettiInstitute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-590, Brazil.ORCID 0000-0003-3913-608X
Martina SchmidtDepartment of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Building 3211, Room 406, 9713 AV Groningen, The Netherlands.ORCID 0000-0003-3075-0630
Emanuel Kennedy-FeitosaMorphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil.
Universidade Federal Rural do Semi-Árido · BRUniversidade de São Paulo · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BRUniversity Medical Center Groningen · NL

Funding

Universidade Federal Rural do Semi-Árido PPP 25/2018 - 23091.014011/2018-05
6 · The paper itself

Abstract

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.

Indexed as

cigaretteeugenolmacrophagesoxidative stresspulmonary inflammation

Identifiers

PMID37371988
PMCPMC10294992
OpenAlexW4380360828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.