Evidence map›Paper›PMID 37371769›Full record

ArticleBiomedicines2023

Prophylactic vs. Therapeutic Effect of Probiotics on the Inflammation Mediated by the NF-κB Pathway in Inflammatory Bowel Conditions.

Saeideh Najafi, Fattah Sotoodehnejadnematalahi, Mohammad Mehdi Amiri, Mohammad Reza Pourshafie, Mahdi Rohani

Abstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. The role ofFood science and biotechnology · 2025
    Article
  9. Microorganisms · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Novel Probiotic BacteriumMicroorganisms · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saeideh NajafiDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran 14778-93855, Iran.ORCID 0000-0002-5520-5711
Fattah SotoodehnejadnematalahiDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran 14778-93855, Iran.ORCID 0000-0002-4287-9792
Mohammad Mehdi AmiriDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155-6619, Iran.ORCID 0000-0002-3563-341X
Mohammad Reza PourshafieDepartment of Bacteriology, Pasteur Institute of Iran, Tehran 13169-43551, Iran.
Mahdi RohaniDepartment of Bacteriology, Pasteur Institute of Iran, Tehran 13169-43551, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotic supplements consumed adequately at the proper time can affect health by modulating inflammatory pathways in gastrointestinal epithelial cells and modifying the resultant inflammatory response. The current study applied in vitro models to investigate the effectiveness of probiotics in modulating inflammatory pathways and altering inflammatory gene expression in gastrointestinal epithelial cells, with the ultimate goal of promoting probiotic consumption as a therapeutic and preventive measure for chronic inflammatory bowel conditions. HT-29 cells were treated with Gram-negative bacteria to evaluate the changes in pathways related to inflammation activities before and after treatment with a

Indexed as

Bifidobacteriuminflammationinflammatory bowel diseaseLactobacillusNF-κBprobiotics

Identifiers

PMID37371769
PMCPMC10296125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.