Evidence map›Paper›PMID 37371646›Full record

ArticleBiomedicines2023

Neuromodulation of the Autonomic Nervous System in Chronic Low Back Pain: A Randomized, Controlled, Crossover Clinical Trial.

Rob Sillevis, Juan Nicolás Cuenca-Zaldívar, Samuel Fernández-Carnero, Beatriz García-Haba, Eleuterio A Sánchez Romero, Francisco Selva-Sarzo

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07034456 (Possible Mechanisms of Action of Magnetic Tape Through Its Application on the Epidermis), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07034456 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Possible Mechanisms of Action of Magnetic Tape Through Its Application on the Epidermis

TypeinterventionalSponsorPatricia Beltra LopezRan2025 to 2026Enrolled30ConditionsHealthy VolunteersArmsTape with mangetic particles, Topical Anesthetic Cream, Control KinesioTape, Moisturizing Cream (control)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Rob SillevisDepartment of Rehabilitation Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.ORCID 0000-0003-2245-0996
Juan Nicolás Cuenca-ZaldívarUniversidad de Alcalá, Facultad de Enfermería y Fisioterapia, Departamento de Fisioterapia, Grupo de Investigación en Fisioterapia y Dolor, 28801 Alcalá de Henares, Spain.
Samuel Fernández-CarneroUniversidad de Alcalá, Facultad de Enfermería y Fisioterapia, Departamento de Fisioterapia, Grupo de Investigación en Fisioterapia y Dolor, 28801 Alcalá de Henares, Spain.ORCID 0000-0003-2893-1627
Beatriz García-HabaFrancisco Selva Physiotherapy Clinic, 46008 Valencia, Spain.
Eleuterio A Sánchez RomeroInterdisciplinary Group on Musculoskeletal Disorders, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.ORCID 0000-0003-0254-6501
Francisco Selva-SarzoPhysiotherapy Faculty, Universitat de València, 46010 Valencia, Spain.ORCID 0000-0001-9731-0950
Universidad de Alcalá · ESFlorida Gulf Coast University · USUniversidad Europea de Canarias · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pain is a societal concern influencing the autonomic nervous system. This system can be captured with automated pupillometry. The direct connection between the epidermal cells and the brain is presented as part of the central nervous system, reflecting the modulation of the autonomic system. This study's aim was to investigate if tape containing magnetic particles (TCMP) has an immediate effect on the autonomic nervous system (ANS) and influences chronic low back pain. Twenty-three subjects completed this study. Subjects were randomized to either receive the control tape (CT) or TCMP first. Each subject underwent a pain provocative pressure test on the spinous process, followed by the skin pinch test and automated pupillometry. Next, the TCMP/control tape was applied. After tape removal, a second provocative spinous process pressure test and skin pinch test were performed. Subjects returned for a second testing day to receive the other tape application. The results demonstrate that TCMP had an immediate significant effect on the autonomic nervous system and resulted in decreased chronic lower back pain. We postulate that this modulation by TCMP s has an immediate effect on the autonomic system and reducing perceived pain, opening a large field of future research.

Indexed as

autonomic nervous systemlow back painneuromodulation therapytranscutaneous

Identifiers

PMID37371646
PMCPMC10295027
OpenAlexW4378527964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.