Evidence map›Paper›PMID 37371626›Full record

ArticleBiomedicines2023

Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis.

Kun Qing, Talissa A Altes, John P Mugler, Jaime F Mata, Nicholas J Tustison, Kai Ruppert, Juliana Bueno, Lucia Flors, Yun M Shim, Li Zhao and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Targeting the epithelium in pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Kun QingDepartment of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Talissa A AltesDepartment of Radiology, University of Missouri, Columbia, MO 65211, USA.
John P MuglerDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Jaime F MataDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Nicholas J TustisonDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0001-9418-5103
Kai RuppertDepartment of Radiology, University of Pennsylvania, Cincinnati, PA 19104, USA.ORCID 0000-0002-7292-6019
Juliana BuenoDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Lucia FlorsDepartment of Radiology, Keck Medical Center, University of Southern California, Los Angeles, CA 90089, USA.
Yun M ShimDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-3780-3371
Li ZhaoDepartment of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
Joanne CassaniDepartment of Radiology, University of Missouri, Columbia, MO 65211, USA.
William G TeagueDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
John S KimDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Zhixing WangDepartment of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0002-8189-0601
Iulian C RusetXemed LLC, Durham, NH 03824, USA.
F William HersmanXemed LLC, Durham, NH 03824, USA.
Borna MehradDepartment of Medicine, University of Florida, Gainesville, FL 32611, USA.
University of Virginia · USCity Of Hope National Medical Center · USUniversity of Missouri · USUniversity of Cincinnati · USUniversity of Florida · USUniversity of New Hampshire · USUniversity of Southern California · USXemed (United States) · USZhejiang University · CN

Funding

Hyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9M
Fibrocytes in human pulmonary fibrosisR01HL098329 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA, ROSE, C EDWARD · 2011 to 2015
$2.7M
Discovery of New Anti-Inflammatory Agents to Treat COPDR01HL132287 · NHLBI · GEORGE MASON UNIVERSITY · PI NOBLE, SCHROEDER M, PAIGE, MIKELL · 2016 to 2019
$2.4M
Simultaneous Xe129 MRI of Regional Lung Ventilation and Gas Uptake in COPDR01HL109618 · NHLBI · UNIVERSITY OF VIRGINIA · PI ALTES, TALISSA A, MUGLER, JOHN P · 2011 to 2015
$2.4M
Role of polyunsaturated fatty acids in pulmonary fibrosisK23HL150301 · NHLBI · UNIVERSITY OF VIRGINIA · PI KIM, JOHN S · 2021 to 2025
$858k
Biology of Leukotrienes in the Pathogenesis of EmphysemaK08HL091127 · NHLBI · UNIVERSITY OF VIRGINIA · PI SHIM, YUN MICHAEL · 2008 to 2012
$643k
Neutrophils and adaptive immunity against invasive aspergillosisR21AI117397 · NIAID · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2015 to 2016
$435k
NIH HHS AI117397NIH HHS HL098329NIH HHS HL109618NIH HHS K23-HL-150301
6 · The paper itself

Abstract

purposeThe existing tools to quantify lung function in interstitial lung diseases have significant limitations. Lung MRI imaging using inhaled hyperpolarized xenon-129 gas ( MATERIALS AND

methodsAfter institutional review board approval and informed consent and in compliance with HIPAA regulations, we performed chest CT, pulmonary function tests (PFTs), and

resultsThe

conclusionThe hyperpolarized

Indexed as

hyperpolarized xenon-129 MRIpulmonary fibrosisusual interstitial pneumonia

Identifiers

PMID37371626
PMCPMC10294784
OpenAlexW4378377213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.