Evidence map›Paper›PMID 37371591›Full record

ArticleBiomolecules2023

Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-Scale Hybrids of Nanofibers and Microparticles.

Jianfeng Zhou, Yelin Dai, Junhao Fu, Chao Yan, Deng-Guang Yu, Tao Yi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  7. Recent Advances in Electrospinning Techniques for Precise Medicine.Cyborg and bionic systems (Washington, D.C.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jianfeng ZhouSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yelin DaiWenqi Middle School, East Jiangchuan Road 980, Shanghai 200240, China.
Junhao FuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Chao YanSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Deng-Guang YuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0001-7825-4498
Tao YiFaculty of Health Sciences and Sports, Macao Polytechnic University, Macau 999078, China.
University of Shanghai for Science and Technology · CNFudan University · CNMacao Polytechnic University · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this nano era, nanomaterials and nanostructures are popular in developing novel functional materials. However, the combinations of materials at micro and macro scales can open new routes for developing novel trans-scale products with improved or even new functional performances. In this work, a brand-new hybrid, containing both nanofibers and microparticles, was fabricated using a sequential electrohydrodynamic atomization (EHDA) process. Firstly, the microparticles loaded with drug (berberine hydrochloride, BH) molecules in the cellulose acetate (CA) were fabricated using a solution electrospraying process. Later, these microparticles were suspended into a co-dissolved solution that contained BH and a hydrophilic polymer (polypyrrolidone, PVP) and were co-electrospun into the nanofiber/microparticle hybrids. The EHDA processes were recorded, and the resultant trans-scale products showed a typical hybrid topography, with microparticles distributed all over the nanofibers, which was demonstrated by SEM assessments. FTIR and XRD demonstrated that the components within the hybrids were presented in an amorphous state and had fine compatibility with each other. In vitro dissolution tests verified that the hybrids were able to provide the designed dual-step drug release profiles, a combination of the fast release step of BH from the hydrophilic PVP nanofibers through an erosion mechanism and the sustained release step of BH from the insoluble CA microparticles via a typical Fickian diffusion mechanism. The present protocols pave a new way for developing trans-scale functional materials.

Indexed as

BerberineNanofibersDelayed-Action PreparationsDiazonium CompoundsFarnesolPolymersBerberineDelayed-Action PreparationsDiazonium Compoundsepoxyhomofarnesyl diazoacetateFarnesolPolymersberberine hydrochloridedual-step releaseelectrospinningelectrosprayinghybridmicroparticlenanofibers

Identifiers

PMID37371591
PMCPMC10295831
OpenAlexW4381252213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.