Evidence map›Paper›PMID 37371580›Full record

ArticleBiomolecules2023

Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators.

Tania Szal, Shweta Singh Chauhan, Philipp Lewe, Fatima-Zahra Rachad, Marina Madre, Laura Paunina, Susanne Witt, Ramakrishnan Parthasarathi, Björn Windshügel

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tania SzalFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.ORCID 0000-0002-9474-032X
Shweta Singh ChauhanComputational Toxicology Facility, Toxicoinformatics & Industrial Research CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.ORCID 0000-0002-1387-7405
Philipp LeweCentre for Structural Systems Biology (CSSB), University Medical Center Hamburg-Eppendorf (UKE), 22607 Hamburg, Germany.
Fatima-Zahra RachadFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.
Marina MadreLatvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Laura PauninaLatvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.ORCID 0000-0002-6309-6017
Susanne WittCentre for Structural Systems Biology (CSSB), University Medical Center Hamburg-Eppendorf (UKE), 22607 Hamburg, Germany.
Ramakrishnan ParthasarathiComputational Toxicology Facility, Toxicoinformatics & Industrial Research CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.ORCID 0000-0001-5417-5867
Björn WindshügelFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.ORCID 0000-0002-4835-3134
Constructor University · DEIndian Institute of Toxicology Research · INLatvijas Organiskās Sintēzes Institūts · LVUniversität Hamburg · DEFraunhofer Institute for Translational Medicine and Pharmacology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efflux pumps are a relevant factor in antimicrobial resistance. In

Indexed as

Escherichia coli ProteinsMembrane Transport ProteinsAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsEscherichia coliPeriplasmAcrB protein, E coliAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsEscherichia coli ProteinsMembrane Transport ProteinsAcrAantimicrobial studiesassay interferencecolloidal aggregatorsdynamic light scatteringE. coliefflux pump inhibitorefflux pumpsmicroscale thermophoresisnano-differential scanning fluorimetryvirtual screening

Identifiers

PMID37371580
PMCPMC10296211
OpenAlexW4380986115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.