Evidence map›Paper›PMID 37371553›Full record

SynthesisBiomolecules2023

In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review.

Robert H Guirguis, Leonard P Tan, Rebecca M Hicks, Aniqa Hasan, Tina D Duong, Xia Hu, Jordan Y S Hng, Mohammad H Hadi, Henry C Owuama, Tamara Matthyssen and 4 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Robert H GuirguisMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0001-7939-5495
Leonard P TanMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0001-8570-7950
Rebecca M HicksMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Aniqa HasanMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Tina D DuongMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Xia HuMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0002-3274-0949
Jordan Y S HngMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Mohammad H HadiMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Henry C OwuamaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Tamara MatthyssenMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Michael McCulloughMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0001-7829-4684
Federica CanforaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4610-6690
Rita PaoliniMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0002-2170-4723
Antonio CelentanoMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.ORCID 0000-0003-4293-2511
The University of Melbourne · AUUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear.

methodsIn March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of Science were screened to identify eligible in vitro studies investigating the effects of antiresorptive and antiangiogenic compounds on orally derived cells.

resultsFifty-nine articles met the inclusion criteria. Bisphosphonates were used in 57 studies, denosumab in two, and sunitinib and bevacizumab in one. Zoledronate was the most commonly used nitrogen-containing bisphosphonate. The only non-nitrogen-containing bisphosphonate studied was clodronate. The most frequently tested tissues were gingival fibroblasts, oral keratinocytes, and alveolar osteoblasts. These drugs caused a decrease in cell proliferation, viability, and migration.

conclusionsAntiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsAngiogenesis InhibitorsDenosumabDiphosphonatesHumansZoledronic AcidAngiogenesis InhibitorsBone Density Conservation AgentsDenosumabDiphosphonatesZoledronic AcidantiangiogenicsantiresorptivesbisphosphonatesMRONJoral tissues

Identifiers

PMID37371553
PMCPMC10296421
OpenAlexW4380368521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.