Evidence map›Paper›PMID 37371533›Full record

ArticleBiomolecules2023

Inhibitory Potential of Synthetic Amino Acid Derivatives against Digestive Enzymes as Promising Hypoglycemic and Anti-Obesity Agents.

Franciane Campos da Silva, Bruna Celeida Silva Santos, Pedro Pôssa de Castro, Giovanni Wilson Amarante, Orlando Vieira de Sousa

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Franciane Campos da SilvaDepartamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Campus Universitário, São Pedro, Juiz de Fora 36036-900, MG, Brazil.
Bruna Celeida Silva SantosDepartamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Campus Universitário, São Pedro, Juiz de Fora 36036-900, MG, Brazil.
Pedro Pôssa de CastroDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, São Pedro, Juiz de Fora 36036-900, MG, Brazil.ORCID 0000-0002-3018-3130
Giovanni Wilson AmaranteDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, São Pedro, Juiz de Fora 36036-900, MG, Brazil.ORCID 0000-0003-1004-5395
Orlando Vieira de SousaDepartamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Campus Universitário, São Pedro, Juiz de Fora 36036-900, MG, Brazil.ORCID 0000-0001-8512-4464
Universidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decades, the increased incidence of metabolic disorders, such as type two diabetes and obesity, has motivated researchers to investigate new enzyme inhibitors. In this study, the inhibitory effects of synthetic amino acid derivatives (PPC80, PPC82, PPC84, PPC89, and PPC101) on the activity of digestive enzymes were assessed using in vitro assays. The inhibitory effect was determined by the inhibition percentage and the 50% inhibitory concentration (IC

Indexed as

Anti-Obesity AgentsHypoglycemic Agentsalpha-GlucosidasesAmino AcidsEnzyme Inhibitorsalpha-GlucosidasesAmino AcidsAnti-Obesity AgentsEnzyme InhibitorsHypoglycemic Agentsamino acid derivativesdigestive enzymesmetabolic disorderspancreatic lipasepancreatic α-amylaseα-glucosidase

Identifiers

PMID37371533
PMCPMC10296036
OpenAlexW4379802185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.