Evidence map›Paper›PMID 37371514›Full record

ArticleBiomolecules2023

Assessing the Resilience of Machine Learning Classification Algorithms on SARS-CoV-2 Genome Sequences Generated with Long-Read Specific Errors.

Bikram Sahoo, Sarwan Ali, Pin-Yu Chen, Murray Patterson, Alexander Zelikovsky

Abstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bikram SahooDepartment of Computer Science, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-6481-2583
Sarwan AliDepartment of Computer Science, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-8121-2168
Pin-Yu ChenIBM Research, IBM T. J. Watson Research Center, Yorktown Heights, NY 10598, USA.ORCID 0000-0003-1039-8369
Murray PattersonDepartment of Computer Science, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-4329-0234
Alexander ZelikovskyDepartment of Computer Science, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0003-4424-4691

Funding

Chemo-neoepitopes as novel immunotherapy for triple negative breast cancerR21CA241044 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI IONOV, YURIJ, MANDOIU, ION · 2021 to 2021
$467k
NCI NIH HHS R21 CA241044
6 · The paper itself

Abstract

The emergence of third-generation single-molecule sequencing (TGS) technology has revolutionized the generation of long reads, which are essential for genome assembly and have been widely employed in sequencing the SARS-CoV-2 virus during the COVID-19 pandemic. Although long-read sequencing has been crucial in understanding the evolution and transmission of the virus, the high error rate associated with these reads can lead to inadequate genome assembly and downstream biological interpretation. In this study, we evaluate the accuracy and robustness of machine learning (ML) models using six different embedding techniques on SARS-CoV-2 error-incorporated genome sequences. Our analysis includes two types of error-incorporated genome sequences: those generated using simulation tools to emulate error profiles of long-read sequencing platforms and those generated by introducing random errors. We show that the spaced

Indexed as

COVID-19SARS-CoV-2AlgorithmsHigh-Throughput Nucleotide SequencingHumansMachine LearningPandemicsSequence Analysis, DNAclassificationembedding methodslong readmachine learningsequencing errorthird-generation single-molecule sequencing (TGS)

Identifiers

PMID37371514
PMCPMC10296223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.