Evidence map›Paper›PMID 37371493›Full record

ReviewBiomolecules2023

Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview.

Ana Druzijanic, Mare Kovic, Marija Roguljic, Livia Cigic, Martina Majstorovic, Ivana Vucenik

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ana DruzijanicDepartment of Dental Medicine, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0002-2049-7136
Mare KovicDepartment of Oral Medicine and Periodontology, School of Medicine, University of Split, 21000 Split, Croatia.
Marija RoguljicDepartment of Dental Medicine, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0003-3752-9074
Livia CigicDepartment of Dental Medicine, University Hospital of Split, 21000 Split, Croatia.
Martina MajstorovicDepartment of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Ivana VucenikDepartment of Medical and Research Technology, University of Maryland School of Medicine, 100 Penn Street, Baltimore, MD 21201, USA.
University of Split · HRUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol (Ins), is abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate essential cellular functions. IP6 has profound modulation effects on macrophages, which warrants further research on the therapeutic benefits of IP6 for inflammatory diseases. Here, we review IP6 as a promising compound that has the potential to be used in various areas of dentistry, including endodontics, restorative dentistry, implantology, and oral hygiene products, due to its unique structure and characteristic properties. Available as a dietary supplement, IP6 + Ins has been shown to enhance the anti-inflammatory effect associated with preventing and suppressing the progression of chronic dental inflammatory diseases. IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights into future use of IP6 in the fields of orthodontics, periodontics, implants, and pediatric dentistry.

Indexed as

InositolPhytic AcidChildHumansInositolPhytic Acidclinical observationsmolecular interactionsperiodontitisphytic acidresolution of inflammationtissue repair

Identifiers

PMID37371493
PMCPMC10296266
OpenAlexW4378904381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.