Evidence map›Paper›PMID 37371471›Full record

ArticleBiomolecules2023

CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis.

Helen Willcockson, Huseyin Ozkan, José Valdés-Fernández, Liubov Arbeeva, Esra Mucahit, Layla Musawwir, Lola B Hooper, Froilán Granero-Moltó, Felipe Prósper, Lara Longobardi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Helen WillcocksonDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
Huseyin OzkanDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
José Valdés-FernándezProgram of Regenerative Medicine, Center for Applied Medical Research (CIMA), Universidad de Navarra, 31008 Pamplona, Spain.
Liubov ArbeevaDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
Esra MucahitDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
Layla MusawwirDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
Lola B HooperDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.
Froilán Granero-MoltóProgram of Regenerative Medicine, Center for Applied Medical Research (CIMA), Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-4817-5232
Felipe PrósperProgram of Regenerative Medicine, Center for Applied Medical Research (CIMA), Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-6115-8790
Lara LongobardiDivision of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, 3300 Thurston Bldg, Campus Box 7280, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0156-847X

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
Role of CCR2 in osteoarthritisR01AR070821 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lara Longobardi · 2017 to 2026
$3.1M
NIAMS NIH HHS P30 AR072580NIAMS NIH HHS R01 AR070821NIH HHS R01AR070821
6 · The paper itself

Abstract

In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology. In this study, we investigated whether

Indexed as

Cartilage, ArticularOsteoarthritisOsteophyteAnimalsBone and BonesDisease ProgressionMiceOsteoblastsPainReceptors, CCR2Receptors, CCR2bonechemokinesosteoarthritis

Identifiers

PMID37371471
PMCPMC10296290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.