Evidence map›Paper›PMID 37371408›Full record

ArticleBrain sciences2023

Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer's Disease, and Mild Cognitive Impairment.

Letteria Tomasello, Leonardo Carlucci, Angelina Laganà, Santi Galletta, Chiara Valeria Marinelli, Massimo Raffaele, Pierluigi Zoccolotti

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. How yoga shapes the brain: a systematic review.Frontiers in neuroscience · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Letteria TomaselloDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Leonardo CarlucciLearning Sciences Hub, Department of Humanities, Letters, Cultural Heritage and Educational Studies, Foggia University, 71121 Foggia, Italy.ORCID 0000-0002-9853-5606
Angelina LaganàDepartment of Biomedical and Dental Sciences, Morphological and Functional Images, 98122 Messina, Italy.
Santi GallettaRéseau Hospitalier Neuchâtelois (RHNe), Service de Neurologie et Neuroréadaptation, 2000 Neuchâtel, Switzerland.
Chiara Valeria MarinelliLearning Sciences Hub, Department of Humanities, Letters, Cultural Heritage and Educational Studies, Foggia University, 71121 Foggia, Italy.ORCID 0000-0002-8806-5655
Massimo RaffaeleDepartment of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Pierluigi ZoccolottiTuscany Rehabilitation Clinic, 52025 Montevarchi, Italy.ORCID 0000-0002-6351-2455
University of Messina · ITUniversity of Foggia · ITHospital Neuchâtel · CHSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study analyzed the efficacy of EEG resting state and neuropsychological performances in discriminating patients with different forms of dementia, or mild cognitive impairment (MCI), compared with control subjects. Forty-four patients with dementia (nineteen patients with AD, and seven with FTD), eighteen with MCI, and nineteen healthy subjects, matched for age and gender, underwent an extensive neuropsychological test battery and an EEG resting state recording. Results showed greater theta activation in posterior areas in the Alzheimer's disease (AD) and Fronto-Temporal Dementia (FTD) groups compared with the MCI and control groups. AD patients also showed more delta band activity in the temporal-occipital areas than controls and MCI patients. By contrast, the alpha and beta bands did not discriminate among groups. A hierarchical clustering analysis based on neuropsychological and EEG data yielded a three-factor solution. The clusters differed for several neuropsychological measures, as well as for beta and theta bands. Neuropsychological tests were most sensitive in capturing an initial cognitive decline, while increased theta activity was uniquely associated with a substantial worsening of the clinical picture, representing a negative prognostic factor. In line with the Research Domains Framework (RDoC) perspective, the joint use of cognitive and neurophysiological data may provide converging evidence to document the evolution of cognitive skills in at-risk individuals.

Indexed as

Alzheimer’sdementiaEEGMCIneuropsychological profile

Identifiers

PMID37371408
PMCPMC10296106
OpenAlexW4380087851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.