ArticleChildren (Basel, Switzerland)2023
Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders.
Henriette H M Dreyer, Eleonora Sofie van Tuyll van Serooskerken, Lisa W Rodenburg, Arnold J N Bittermann, Hubertus G M Arets, Ellen M B P Reuling, Johannes W Verweij, Eric G Haarman, David C van der Zee, Stefaan H A J Tytgat and 4 more
Open access · goldAbstract read
In one paragraphArticle in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors at 4 institutions in 1 country.
Henriette H M DreyerDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.ORCID 0000-0001-9925-864X Eleonora Sofie van Tuyll van SerooskerkenDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.
Lisa W RodenburgDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.ORCID 0000-0002-8113-4304 Arnold J N BittermannPediatric Upper Gastrointestinal and Airway Treatment Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.
Hubertus G M AretsDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.
Ellen M B P ReulingDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.ORCID 0000-0002-1836-2486 Johannes W VerweijDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.ORCID 0000-0003-0559-0495 Eric G HaarmanDepartment of Paediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands.
David C van der ZeeDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.
Stefaan H A J TytgatDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.ORCID 0000-0001-5486-3766 Cornelis K van der EntDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.ORCID 0000-0002-2501-4121 Jeffrey M BeekmanDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.ORCID 0000-0003-4886-3756 Gimano D AmatngalimDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, 3508 AB Utrecht, The Netherlands.ORCID 0000-0003-3442-1754 Maud Y A LindeboomDepartment of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands.ORCID 0000-0003-1222-1022 University Medical Center Utrecht · NLUtrecht University · NLEmma Kinderziekenhuis · NLWilhelmina Children's Hospital · NL
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory tract disorders are in part caused by alterations in airway epithelial cell functions such as the activity of motile cilia. This can be studied using airway epithelial cell culture models of patients with EA. Therefore, the aim of this study was to evaluate the feasibility to culture and functionally characterize motile cilia function in the differentiated air-liquid interface cultured airway epithelial cells and 3D organoids derived from nasal brushings and bronchoalveolar lavage (BAL) fluid from children with EA. We demonstrate the feasibility of culturing differentiated airway epithelia and organoids of nasal brushings and BAL fluid of children with EA, which display normal motile cilia function. EA patient-derived airway epithelial cultures can be further used to examine whether alterations in epithelial functions contribute to respiratory disorders in EA.
Indexed as
airway epitheliumesophageal atresiaorganoidsprimary ciliary dyskinesiatracheal anomaly
Identifiers
PMID37371252
PMCPMC10296877
OpenAlexW4379517754
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