Evidence map›Paper›PMID 37371128›Full record

ArticleCells2023

Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model.

Jieun Kim, Chanbin Lee, Jinsol Han, Hayeong Jeong, Sihyung Wang, Yung Hyun Choi, Youngmi Jung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jieun KimInstitute of System Biology, Pusan National University, Pusan 46241, Republic of Korea.
Chanbin LeeInstitute of System Biology, Pusan National University, Pusan 46241, Republic of Korea.
Jinsol HanDepartment of Integrated Biological Science, College of Natural Sciences, Pusan National University, Pusan 46241, Republic of Korea.ORCID 0000-0002-5317-9409
Hayeong JeongDepartment of Integrated Biological Science, College of Natural Sciences, Pusan National University, Pusan 46241, Republic of Korea.
Sihyung WangNew Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
Yung Hyun ChoiDepartment of Biochemistry, Dong-Eui University College of Korean Medicine, Pusan 47227, Republic of Korea.ORCID 0000-0002-1454-3124
Youngmi JungDepartment of Integrated Biological Science, College of Natural Sciences, Pusan National University, Pusan 46241, Republic of Korea.ORCID 0000-0003-2189-0658
Pusan National University · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRDong-Eui University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis is the most common feature of liver disease, and activated hepatic stellate cells (HSCs) are the main contributors to liver fibrosis. Thus, finding key targets that modulate HSC activation is important to prevent liver fibrosis. Previously, we showed that thymosin β4 (Tβ4) influenced HSC activation by interacting with the Hedgehog pathway in vitro. Herein, we generated Tβ4 conditional knockout (Tβ4-flox) mice to investigate in vivo functions of Tβ4 in liver fibrosis. To selectively delete Tβ4 in activated HSCs, double-transgenic (DTG) mice were generated by mating Tβ4-flox mice with α-smooth muscle actin (α-Sma)-Cre-ER

Indexed as

Hepatic Stellate CellsLiver CirrhosisThymosinAnimalsDisease Models, AnimalHedgehog ProteinsMiceMice, TransgenicThymosin beta(4)Hedgehog ProteinsThymosinThymosin beta(4)Tmsb4x protein, mousehepatic stellate cellsliver fibrosisTβ4Tβ4-flox transgenic mice

Identifiers

PMID37371128
PMCPMC10297343
OpenAlexW4381149155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.