Evidence map›Paper›PMID 37371092›Full record

ReviewCells2023

The Signaling Mechanism of Remote Postconditioning of the Heart: Prospects of the Use of Remote Postconditioning for the Treatment of Acute Myocardial Infarction.

Vyacheslav V Ryabov, Evgenii V Vyshlov, Leonid N Maslov, Alexandr V Mukhomedzyanov, Natalia V Naryzhnaya, Alla A Boshchenko, Aleksandra E Gombozhapova, Julia O Samoylova

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Infarct-Limiting Efficacy of KBulletin of experimental biology and medicine · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vyacheslav V RyabovCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0002-4358-7329
Evgenii V VyshlovCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.
Leonid N MaslovCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0002-6020-1598
Alexandr V MukhomedzyanovCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0003-1808-556X
Natalia V NaryzhnayaCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0003-2264-1928
Alla A BoshchenkoCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0001-6009-0253
Aleksandra E GombozhapovaCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0003-1281-3714
Julia O SamoylovaCardiology Research Institute, Tomsk National Research Medical Center of the RAS, 634012 Tomsk, Russia.ORCID 0000-0001-7545-7388
Tomsk National Research Medical Center · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myocardial infarction (AMI) remains the leading cause of mortality in the world, highlighting an urgent need for the development of novel, more effective approaches for the treatment of AMI. Remote postconditioning (RPost) of the heart could be a useful approach. It was demonstrated that RPost triggers infarct size reduction, improves contractile function of the heart in reperfusion, mitigates apoptosis, and stimulates autophagy in animals with coronary artery occlusion and reperfusion. Endogenous opioid peptides and adenosine could be involved in RPost. It was found that kinases and NO-synthase participate in RPost. KATP channels, MPT pore, and STAT3 could be hypothetical end-effectors of RPost. Metabolic syndrome and old age abolish the cardioprotective effect of RPost in rats. The data on the efficacy of RPost in clinical practice are inconsistent. These data are discussed in the review.

Indexed as

Myocardial InfarctionMyocardial Reperfusion InjuryAnimalsHeartMyocardiumRatsSignal Transductionend-effectorheartischemiakinasesremote postconditioningreperfusion

Identifiers

PMID37371092
PMCPMC10297492
OpenAlexW4380681471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.