Evidence map›Paper›PMID 37371050›Full record

ReviewCells2023

The Role of Inflammation in CKD.

Saurav Prashant Kadatane, Matthew Satariano, Michael Massey, Kai Mongan, Rupesh Raina

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 4 pooled it
38.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 4 syntheses or guidelines pooled it, 247 citations in OpenAlex.

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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Saurav Prashant KadataneDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.ORCID 0000-0002-3589-8696
Matthew SatarianoDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Michael MasseyDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Kai MonganDepartment of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Rupesh RainaAkron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH 44302, USA.ORCID 0000-0003-3892-8376
Northeast Ohio Medical University · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade inflammation is a substantial factor in its development and progression and has correlated with increased mortality and cardiovascular problems. This low-grade inflammation is a product of dysregulation of the normal balance between pro- and anti-inflammatory markers. Various factors such as increased innate immune system activation, reactive oxygen species production, periodontal disease, dysregulation of anti-inflammatory systems and intestinal dysbiosis result in the dysregulation of this balance. Furthermore, this low-grade inflammation has down-effects such as hypertension, renal fibrosis and acceleration of renal function decline. Moreover, low-grade inflammation over time has been linked to malignancy in CKD. As CKD progresses, many patients require dialysis, which has a negative bidirectional relationship with persistent inflammation. Treatment options for inflammation in CKD are vast, including cytokine inhibitors, statins and diets. However, more research is needed to create a standardized management plan. In this review, we will examine the normal physiology of the kidney and its relationship with the immune system. We will then delve into the pathology behind persistent inflammation, the various causes of inflammation, the downstream effects of inflammation, dialysis and potential treatments for inflammation in CKD.

Indexed as

Renal DialysisRenal Insufficiency, ChronicAdultAnti-Inflammatory AgentsHumansInflammationKidneyAnti-Inflammatory Agentschronic kidney diseaseimmuneinflammation

Identifiers

PMID37371050
PMCPMC10296717
OpenAlexW4380050579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.