Evidence map›Paper›PMID 37371047›Full record

ReviewCells2023

A Comprehensive Review of miRNAs and Their Epigenetic Effects in Glioblastoma.

Hera Hasan, Mohammad Afzal, Javier S Castresana, Mehdi H Shahi

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

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  17. mAmerican journal of cancer research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Hera HasanInterdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, India.ORCID 0009-0006-2980-3714
Mohammad AfzalDepartment of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.ORCID 0000-0001-8189-8753
Javier S CastresanaDepartment of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain.ORCID 0000-0002-2373-482X
Mehdi H ShahiInterdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, India.ORCID 0000-0001-9589-4382
Aligarh Muslim University · INUniversidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is the most aggressive form of brain tumor originating from glial cells with a maximum life expectancy of 14.6 months. Despite the establishment of multiple promising therapies, the clinical outcome of glioblastoma patients is abysmal. Drug resistance has been identified as a major factor contributing to the failure of current multimodal therapy. Epigenetic modification, especially DNA methylation has been identified as a major regulatory mechanism behind glioblastoma progression. In addition, miRNAs, a class of non-coding RNA, have been found to play a role in the regulation as well as in the diagnosis of glioblastoma. The relationship between epigenetics, drug resistance, and glioblastoma progression has been clearly demonstrated.

Indexed as

GlioblastomaMicroRNAsAntineoplastic Agents, AlkylatingDacarbazineDNA MethylationDNA Modification MethylasesDNA Repair EnzymesEpigenesis, GeneticHumansTemozolomideTumor Suppressor ProteinsAntineoplastic Agents, AlkylatingDacarbazineDNA Modification MethylasesDNA Repair EnzymesMicroRNAsTemozolomideTumor Suppressor ProteinsDNA methylationepigeneticsglioblastomamiRNAtemozolomide

Identifiers

PMID37371047
PMCPMC10297163
OpenAlexW4380050001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.