Evidence map›Paper›PMID 37371046›Full record

ArticleCells2023

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models.

Julio C Corral-Serrano, Paul E Sladen, Daniele Ottaviani, Olivia F Rezek, Dimitra Athanasiou, Katarina Jovanovic, Jacqueline van der Spuy, Brian C Mansfield, Michael E Cheetham

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Eupatilin alleviates right ventricular fibrosis in rats with pulmonary hypertension induced by monocrotaline.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
  6. USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy.Investigative ophthalmology & visual science · 2025
    Article
  7. Article
  8. The Kinesin Motor Kif9 Disrupts Primary Cilia Length by Mispositioning Centriolar Satellites.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  9. Article
  10. Retinal Organoids: Innovative Tools for Understanding Retinal Degeneration.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Cell-cell interaction in the pathogenesis of inherited retinal diseases.Frontiers in cell and developmental biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Julio C Corral-SerranoUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.ORCID 0000-0002-4277-4931
Paul E SladenUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Daniele OttavianiUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.ORCID 0000-0002-1946-7351
Olivia F RezekUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Dimitra AthanasiouUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Katarina JovanovicUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Jacqueline van der SpuyUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Brian C MansfieldEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B, Rockledge Drive, Montgomery County, MD 20892, USA.ORCID 0000-0002-8533-2789
Michael E CheethamUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
University College London · GBNational Institutes of Health · USUniversity of Padua · IT

Funding

Medical Research Council MR/P02582X/1Wellcome Trust 205041/Z/16/Z
6 · The paper itself

Abstract

The photoreceptor outer segment is a highly specialized primary cilium that is essential for phototransduction and vision. Biallelic pathogenic variants in the cilia-associated gene

Indexed as

CiliaCiliopathiesAntigens, NeoplasmCytoskeletal ProteinsFlavonoidsHumansLeber Congenital AmaurosisNeoplasm ProteinsRhodopsinAntigens, NeoplasmCytoskeletal ProteinseupatilinFlavonoidsNeoplasm ProteinsRhodopsinCEP290ciliopathyciliumeupatilinLeber congenital amaurosis (LCA)photoreceptorretinaretinal organoid

Identifiers

PMID37371046
PMCPMC10297203
OpenAlexW4379798946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.