Evidence map›Paper›PMID 37370993›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Developing an Artificial Intelligence-Based Representation of a Virtual Patient Model for Real-Time Diagnosis of Acute Respiratory Distress Syndrome.

Chadi S Barakat, Konstantin Sharafutdinov, Josefine Busch, Sina Saffaran, Declan G Bates, Jonathan G Hardman, Andreas Schuppert, Sigurður Brynjólfsson, Sebastian Fritsch, Morris Riedel

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chadi S BarakatJülich Supercomputing Centre, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0002-4017-609X
Konstantin SharafutdinovSMITH Consortium of the German Medical Informatics Initiative, 07747 Leipzig, Germany.ORCID 0000-0002-9604-5742
Josefine BuschJülich Supercomputing Centre, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0001-8372-2161
Sina SaffaranSchool of Engineering, University of Warwick, Coventry CV4 7AL, UK.
Declan G BatesSchool of Engineering, University of Warwick, Coventry CV4 7AL, UK.
Jonathan G HardmanSchool of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-8959-8058
Andreas SchuppertSMITH Consortium of the German Medical Informatics Initiative, 07747 Leipzig, Germany.ORCID 0000-0003-3783-6605
Sigurður BrynjólfssonSchool of Engineering and Natural Science, University of Iceland, 107 Reykjavik, Iceland.ORCID 0000-0001-9435-2258
Sebastian FritschJülich Supercomputing Centre, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0002-8350-8584
Morris RiedelJülich Supercomputing Centre, Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0003-1810-9330

Funding

European Union 951732European Union 951733Federal Ministry of Education and Research 01ZZ1803M
6 · The paper itself

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a condition that endangers the lives of many Intensive Care Unit patients through gradual reduction of lung function. Due to its heterogeneity, this condition has been difficult to diagnose and treat, although it has been the subject of continuous research, leading to the development of several tools for modeling disease progression on the one hand, and guidelines for diagnosis on the other, mainly the "Berlin Definition". This paper describes the development of a deep learning-based surrogate model of one such tool for modeling ARDS onset in a virtual patient: the Nottingham Physiology Simulator. The model-development process takes advantage of current machine learning and data-analysis techniques, as well as efficient hyperparameter-tuning methods, within a high-performance computing-enabled data science platform. The lightweight models developed through this process present comparable accuracy to the original simulator (per-parameter R

Indexed as

ARDShigh-performance computingICUmachine learningsurrogate modelvirtual patient

Identifiers

PMID37370993
PMCPMC10297554

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.