ReviewDiagnostics (Basel, Switzerland)2023
Perfusion Status in Lacunar Stroke: A Pathophysiological Issue.
Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis.Medicine · 2026Pooled it
- CT Perfusion in lacunar stroke: a powerful tool to enhance lacunar stroke detection and prediction of patients' outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Drug-Induced Amyloid-Related Imaging Abnormalities: A Neurovascular Perspective on Risk Assessment.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Blood Glucose Levels and Stroke Severity in Patients with Acute Small Subcortical Infarct.Brain sciences · 2025Article
- Imaging patterns and prognosis of proximal and distal small subcortical infarcts.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Lenticulostriate arteries (LSA) sign in T occlusion A transient vasomotor phenomenon.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- CT Perfusion imaging as prognostic factor for outcome of lacunar stroke.Neuroradiology · 2024Article
- Progression of enlarged perivascular spaces contributes to occurrence of silent lacunar infarction in the elderly.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Posterior reversible encephalopathy syndrome and acute ischemic stroke: an underreported association.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Small subcortical ischemic infarction and other DWI lesions establish predictive model for MES.Frontiers in neurology · 2024Article
- CT Perfusion in Lacunar Stroke: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Computed tomography perfusion imaging-guided intravenous thrombolysis in acute minor ischemic stroke.Frontiers in neurology · 2023Article
- The value of computed tomography perfusion deficit volumes in acute isolated brainstem infarction.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of lacunar infarction is an evolving and debated field, where relevant information comes from histopathology, old anatomical studies and animal models. Only in the last years, have neuroimaging techniques allowed a sufficient resolution to directly or indirectly assess the dynamic evolution of small vessel occlusion and to formulate hypotheses about the tissue status and the mechanisms of damage. The core-penumbra concept was extensively explored in large vessel occlusions (LVOs) both from the experimental and clinical point of view. Then, the perfusion thresholds on one side and the neuroimaging techniques studying the perfusion of brain tissue were focused and optimized for LVOs. The presence of a perfusion deficit in the territory of a single small perforating artery was negated for years until the recent proposal of the existence of a perfusion defect in a subgroup of lacunar infarcts by using magnetic resonance imaging (MRI). This last finding opens pathophysiological hypotheses and triggers a neurovascular multidisciplinary reasoning about how to image this perfusion deficit in the acute phase in particular. The aim of this review is to summarize the pathophysiological issues and the application of the core-penumbra hypothesis to lacunar stroke.
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