ArticleCancers2023
Fat-Containing Soft Tissue Tumors in Children, Adolescents, and Young Adults: Which Require Biopsy?
Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Lipoblastoma of the head and neck in children: a single-institution study.BMC pediatrics · 2026Article
- Ultrasonography of benign pediatric fibrous and adipocytic lumps.Pediatric radiology · 2026Review
- MORTALITY PROFILE FROM PEDIATRIC BONE NEOPLASIA IN MINAS GERAIS (2015-2024).Acta ortopedica brasileira · 2026Article
- Intraoral Lipoma on the Palate of an 11-Year-Old Patient: A Case Report.Reports (MDPI) · 2025Article
- Epidemiology and clinicopathological features of soft tissue tumors in adolescents: a cross-sectional study.BMC pediatrics · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo confirm the overall benignity of fat-containing soft tissue tumors (STT) on a pediatric cohort and to define the clinical and imaging features that warrant a biopsy.
methodsA retrospective monocentric study was conducted on patients aged less than 25 years consecutively referred for fat-containing STT to our Comprehensive Cancer Center between 1998 and 2022. Tumor imaging characteristics at diagnosis (US, CT, or MRI) were correlated with pathology.
resultsThe database extraction identified 63 fat-containing tumors with clinical, histologic, and imaging data available for review. In total, 58 (92%) were benign tumors: 36 lipoblastomas and lipomas, 12 fibrous hamartomas of infancy (FHI), 5 lipofibromatosis, 2 lipomas arborescens, 2 lipomatosis and 1 spindle-cell lipoma. Five patients (8%) were diagnosed with liposarcoma. Factors significantly correlated with malignancy were age >10 years old (
conclusionMost fat-containing STT in children may be classified as benign tumors based on clinics and imaging. The indication for biopsy could be limited to patients aged 10 years or more with either a cancer-predisposing condition or imaging features demonstrating either a low-fat component (<25%) or the presence of myxoid zones.
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