Evidence map›Paper›PMID 37370836›Full record

ReviewCancers2023

The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas.

Miguel Alonso-Juarranz, Marta Mascaraque, Elisa Carrasco, Tamara Gracia-Cazaña, Oscar De La Sen, Yolanda Gilaberte, Salvador Gonzalez, Ángeles Juarranz, Farzin Falahat

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miguel Alonso-JuarranzOral and Maxillofacial Surgery Service, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0002-9918-8984
Marta MascaraqueDepartment of Biology, Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0002-9677-921X
Elisa CarrascoDepartment of Biology, Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0002-0817-1627
Tamara Gracia-CazañaDepartment of Dermatology, Miguel Servet University Hospital, Instituto Investigación Sanitaria Aragón (IIS), 50009 Zaragoza, Spain.ORCID 0000-0002-0523-2076
Oscar De La SenOral and Maxillofacial Surgery Service, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0002-3582-7177
Yolanda GilaberteDepartment of Dermatology, Miguel Servet University Hospital, Instituto Investigación Sanitaria Aragón (IIS), 50009 Zaragoza, Spain.ORCID 0000-0001-8034-3617
Salvador GonzalezDepartment of Experimental Dermatology and Skin Biology, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, 28034 Madrid, Spain.ORCID 0000-0001-9282-4784
Ángeles JuarranzDepartment of Biology, Universidad Autónoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0002-6574-2887
Farzin FalahatOral and Maxillofacial Surgery Service, Hospital Clínico San Carlos, 28040 Madrid, Spain.

Funding

Instituto de Salud Carlos III PI18/00858; PI18/00708; PI21/00953 and PI21/00315
6 · The paper itself

Abstract

Squamous cell carcinomas arise from stratified squamous epithelia. Here, a comparative analysis based on recent studies defining the genetic alterations and composition of the stroma of oral and cutaneous squamous cell carcinomas (OSCC and CSCC, respectively) was performed. Both carcinomas share some but not all histological and genetic features. This review was focused on how mutations in tumor suppressor genes and protooncogenes cooperate to determine the differentiation, aggressiveness, and metastatic potential of OSCC and CSCC. In fact, driver mutations in tumor suppressor genes are more frequently observed in OSCC than CSCC. These include mutations in

Indexed as

cancer-associated fibroblastscutaneous squamous cell carcinomaimmune cellsoral squamous cell carcinomatertiary lymphoid structurestumor microenvironment

Identifiers

PMID37370836
PMCPMC10296732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.